Nano-scale contrast agents and methods of use
AssigneeMarval Pharma, Inc.
InventorsAnanth Annapragada, Ravi V. Bellamkonda, Efstathios Karathanasis, Russell M. Lebovitz
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Abstract
Compositions and methods are disclosed for evaluating a subject's vasculature integrity, for differentiating between a malignant lesion and a benign lesion, for evaluating the accessibility of a tumor to nano-sized therapeutics, for treating tumors, and for live or real time monitoring of a nano-probe's biodistribution.
Claims18
A method for evaluating a subject's vasculature integrity, the method comprising:
- introducing a composition into the subject's vasculature, the composition comprising:
- liposomes, the liposomes encapsulating one or more iodinated nonradioactive contrast-enhancing agents, and the liposomes comprising:
- cholesterol,
- at least one phospholipid, and
- at least one phospholipid which is derivatized with a polymer chain,
- wherein the average diameter of the liposomes is less than 150 nanometers;
- generating images of the subject's vasculature;
- and
- analyzing the images to detect a leak in the subject's vasculature, the leak in the subject's vasculature being caused by inflammation or angiogenesis, provided that the inflammation or angiogenesis excludes cancer, stroke, aneurism, healing, and trauma.
A method for predicting a probability of success of a nano-chemotherapy in a subject having a tumor, the method comprising:
- introducing a composition into the subject's vasculature, the composition comprising:
- liposomes, the liposomes encapsulating one or more iodinated nonradioactive contrast-enhancing agents, and the liposomes comprising:
- cholesterol,
- at least one phospholipid, and
- at least one phospholipid which is derivatized with a polymer chain,
- wherein the average diameter of the liposomes is less than 150 nanometers;
- generating one or more images of the tumor in a subject;
- determining an uptake of the composition by the tumor in the subject according to the one or more images of the tumor in the subject;
- and
- predicting the response of the tumor in the subject to the nanoparticle chemotherapy according to the uptake of the composition by the tumor in the subject.
A method for treating a subject having a tumor with a nano-chemotherapy, the method comprising:
- introducing a composition into the subject's vasculature, the composition comprising:
- liposomes, the liposomes encapsulating one or more iodinated nonradioactive contrast-enhancing agents, and the liposomes comprising:
- cholesterol,
- at least one phospholipid, and
- at least one phospholipid which is derivatized with a polymer chain,
- wherein the average diameter of the liposomes is less than 150 nanometers;
- generating one or more images of the tumor in a subject;
- determining an uptake of the composition by the tumor in the subject according to the one or more images of the tumor in the subject;
- predicting the response of the tumor in the subject to the nanoparticle chemotherapy according to the uptake of the composition by the tumor in the subject;
- and
- administering the nano-chemotherapy to the subject according to the predicted response of the tumor to the nanoparticle chemotherapy.
Dependencies are inferred from the claim text.