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AssigneeLeibniz-Institut fuer Neurobiologie Stiftung des Oeffentlichen Rechts
InventorsIryna Ziabreva, Petra Henrich-Noack, Juergen Goldschmidt, Kathrin Baldauf, Henning Scheich, Klaus G. Reymann, Ulrich H. Schroeder, Claudia Pforte, Monika Riek-Burchardt
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The present invention relates to a diagnostic substance, containing at least one complex of lipophilic anions and metal ions, wherein the lipophilic anions are selected from the group comprising: triethylene tetramine dihydrochloride (TETA), ethyl cysteinate dimer (ECD), methoxyisobutylisonitrile (MIBI), HMPAO (d,l-hexamethylpropylene aminoxime), ethylenediamine N,N,N′,N′-tetraacetanilide (EDTAN), dimethyldithiocarbamate (DMC) and diethyldithiocarbamate (DDC) and glycine N,N′-[1,2-ethanediylbis(oxy-2,1-phenylene)]bis [N-(carboxymethyl)-1,1′-bis[2-(octadecyloxy)ethyl]ester (DP-109), and wherein the metal ions are selected from the group comprising thallium isotopes, lead isotopes, cobalt isotopes and manganese isotopes, together with solvents, adjuvants and/or vehicles. The diagnostic substance is used for investigating metabolic processes in the brain and/or central nervous system (CNS).
A method for investigating changes in cation metabolism in the brain, the method comprising the steps of:
A method of investigating changes in cation metabolism in the brain for the distinction of healthy and damaged brain tissue over time, the method comprising the steps of:
Dependencies are inferred from the claim text.