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US 8,911,690 B2Granted
Devices for the production of cell clusters of defined cell numbers and cluster sizes
AssigneeUniversitäT ZüRich
InventorsPatrick Kugelmeier, Roger Lehmann, Wolfgang Moritz, Richard Zuellig
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Abstract
Devices for the in vitro aggregation of cells. The devices are characterized by containing special ground cavities allowing cluster formation to take place when a cell suspension is seeded onto the device. Further, the present invention relates to a method for aggregating cells and the use of the devices of the present invention for the aggregation of cells.
Claims14
Device for the aggregation of cells,
- wherein the device comprises a plurality of cavities for receiving one or more than one cell,
- wherein the cavities are pyramidal cavities having spherical bottoms with rounded tips,
- wherein the pyramidal cavities have rounded edges between the rounded tips and respective bases of the pyramidal cavities,
- wherein a space between the cavities is less than 20 μm, and
- wherein a radius of the rounded edges increases from a first radius at the bases of the pyramidal cavities to a larger second radius at the rounded tips.
2 more elements
Dependencies are inferred from the claim text.