Device for collecting and triggered release of a biological sample
AssigneePreanalytix GmbH
InventorsThomas Hanselle, Markus Sprenger-Haussels, Christian Lenz, Daniel Groelz, Uwe Oelmueller
Life of this patent
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Abstract
The invention relates to a system for collecting a biological sample comprising a container having at least one open end, a closure fitting on or in said at least one open end, a holding element connected to said closure and a solid matrix on which said biological sample is deposited, and optionally at least one processing agent, wherein said solid matrix is at least partially transferable into a liquid or dissolved state by changing at least one physico-chemical property of the environment of said matrix without disintegration of the biomolecules comprised in said biological sample deposited on said matrix.
Claims23
A system for collecting a biological sample directly from a source comprising:
- a container having at least one open end,
- a closure fitting on or in said at least one open end,
- a holding element connected to said closure,
- at least one chaotropic substance, and
- a solid matrix on which said biological sample can be deposited, the solid matrix comprising a low melting agarose with a melting point below 65° C.,
- wherein material of said solid matrix is at least partially transferable into a liquid state and/or can be dissolved, in the presence of the at least one chaotropic substance, and optionally in the presence of at least one substance of high ionic strength,
- wherein said matrix is at least substantially solid under collection conditions, and
- wherein said holding element is adapted to hold said solid matrix, and
- further comprising at least one element for at least partially transferring said material of said solid matrix from a solid state into a liquid and/or dissolved state selected from the group consisting of:
- at least one solvent in which the material of said solid matrix is soluble,
- at least one reagent,
- at least one enzyme, and
- at least one pH modifier.
A system for collecting a biological sample directly from a source comprising:
- a container having at least one open end,
- a closure fitting on or in said at least one open end,
- a holding element connected to said closure,
- at least one chaotropic substance, and
- a solid matrix on which said biological sample can be deposited, the solid matrix comprising a low melting agarose with a melting point below 65° C.,
- wherein material of said solid matrix is at least partially transferable into a liquid state and/or can be dissolved, in the presence of the at least one chaotropic substance, and optionally in the presence of at least one substance of high ionic strength,
- wherein said matrix is at least substantially solid under collection conditions, and
- wherein said holding element is adapted to hold said solid matrix,
- wherein the system optionally further comprises a device for local heating and/or cooling of the solid matrix;
- and
- wherein the material of said solid matrix is at least partially meltable by increasing the temperature, and wherein the material of said solid matrix is solid at physiological temperatures and is transferrable to the liquid state at a temperature from 45° C. to 95° C.
A system for collecting a biological sample comprising
- a container having at least one open end,
- a closure fitting on or in said at least one open end,
- a holding element connected to said closure,
- a solid matrix on which said biological sample can be deposited, the solid matrix comprising a low melting agarose with a melting point below 65° C., and
- at least one chaotropic substance,
- wherein material of said solid matrix is at least partially transferable into a liquid and/or dissolved state by changing at least one physico-chemical property of the environment of said matrix without disintegration of biomolecules comprised in said biological sample when said sample is deposited on said matrix, in the presence of the at least one chaotropic substance, and optionally in the presence of at least one substance of high ionic strength,
- wherein said solid matrix is at least substantially solid under collection conditions, and
- wherein said holding element is adapted to hold said solid matrix, and
- further comprising at least one element for changing at least one physico-chemical property of the environment selected from the group consisting of:
- at least one solvent in which the material of said solid matrix is soluble,
- at least one reagent,
- at least one enzyme,
- at least one pH modifier, and
- a device for local heating and/or cooling of the solid matrix.
Dependencies are inferred from the claim text.