Low-permeability, laser-activated drug delivery device

An implantable drug delivery device comprising:

• a first shell element with a first enclosed cavity volume, wherein the first shell element forms a low-permeability barrier, and wherein the first shell element is configured to absorb light irradiation from a laser source, the light irradiation causing a breach in the first shell element;
• a first dose of an active pharmaceutical ingredient contained in the first enclosed cavity volume, wherein the first dose of the active pharmaceutical ingredient is released when the first shell element is breached;
• a second shell element with a second enclosed cavity volume, wherein the second shell element forms a low-permeability barrier;
• and
• a second dose of the active pharmaceutical ingredient contained in the second enclosed cavity volume, wherein the device releases time-delayed, multiple doses of the active pharmaceutical ingredient from a single laser activation of the first shell element.