System and method for mixing the contents of two containers

A system for mixing the contents of a first container and a second container, the system comprising:

• a first container comprising (i) an opening to a cavity containing a first substance, (ii) a stopper sealing the opening, (iii) at least one axial locking member, and (iv) at least one unlocking member, wherein the at least one unlocking member comprises a protrusion extending radially from the first container, and
• a second container containing a second substance, wherein the second container comprises a port assembly comprising a port housing and a main body, the main body configured to receive the first container and to rotate relative to the port housing, wherein rotation of the main body relative to the port housing places the first container and the second container in fluid communication,
• wherein the main body comprises at least one retention tab constructed to engage the at least one axial locking member of the first container to prevent axial removal of the first container from the main body after the first container has been connected to the main body, and wherein the main body further comprises a locking mechanism constructed to prevent rotation of the main body relative to the port housing when the first container is not connected to the main body, wherein the at least one unlocking member of the first container is constructed to unlock the locking mechanism when the first container is connected to the main body.

A medicament container comprising:

• an opening to a cavity containing a first substance;
• a stopper sealing the opening;
• at least one axial locking member, wherein the at least one axial locking member is configured to prevent axial removal of the medicament container from a port assembly of a second container after the medicament container is connected to a port assembly of a second container;
• via engagement of the at least one axial locking member of the medicament container and a retainer of a port assembly of a second container;
• and
• at least one unlocking member, wherein the at least one unlocking member comprises a protrusion extending radially from the medicament container, wherein the at least one unlocking member is configured to unlock a rotational locking mechanism associated with a port assembly of a second container when the medicament container is connected to a port assembly of a second container, thereby allowing a retainer of a port assembly of a second container to rotate relative to a port housing of a port assembly of a second container, which places the medicament container and a second container in fluid communication.