Multipart fluid system and a system for regional citrate anticoagulation in an extracorporeal blood circuit
AssigneeGambro Lundia AB
InventorJan Sternby
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Abstract
The present invention concerns a multipart fluid system for use in CRRT, wherein the multipart fluid system comprises an anticoagulation fluid and at least one fluid from the group consisting of a dialysis fluid and an infusion fluid. According to the invention the anticoagulation fluid comprises at least 8 mM citrate, and the dialysis fluid and/or infusion fluid comprises 2-8 mM citrate and 1-5 mM total calcium. The present invention further concerns a system for regional citrate anticoagulation in an extracorporeal blood circuit.
Claims32
A multipart fluid system for use in continuous renal replacement therapy (CRRT), said multipart fluid system comprising:
- a first vessel configured to be in fluid communication with an extracorporeal blood passage of a CRRT blood treatment apparatus;
- a second vessel configured to be in fluid communication with the extracorporeal blood passage;
- an anticoagulation fluid in the first vessel and including at least 8 mM citrate, and
- at least one fluid in the second vessel, wherein the at least one fluid is from a group consisting of a dialysis fluid and an infusion fluid, and said at least one fluid comprises 2-8 mM citrate and 1-5 mM total calcium.
A system for regional citrate anticoagulation in an extracorporeal blood circuit for a continuous renal replacement therapy (CRRT) apparatus, the system including an arterial blood line configured to be connected to a vascular access device for withdrawing blood from a patient and a venous blood line configured to be connected to the vascular access for returning blood to the patient, the system comprising:
- a filter in the CRRT apparatus, the filter including a dialysate side and a blood side, which blood side is in fluid communication with the arterial and venous blood lines;
- a pre-filter infusion line in the CRRT apparatus and connected to the arterial blood line upstream the filter and connected to an anticoagulation fluid source containing at least 8 mM citrate to be infused into the blood stream in the arterial blood line;
- and
- a post-filter infusion line in the CRRT apparatus and connected to the venous blood line downstream the filter and connected to an infusion fluid source comprising 2-8 mM citrate and 1-5 mM total calcium to be infused into the blood stream in the venous blood line.
A system for regional citrate anticoagulation in an extracorporeal blood circuit for a continuous renal replacement therapy (CRRT) apparatus, the system comprising an arterial blood line configured to be connected to a vascular access for withdrawing blood from a patient and a venous blood line configured to be connected to the vascular access for returning blood to the patient, the system comprising:
- a filter for the CRRT apparatus, the filter including a dialysate side and a blood side, which blood side is in fluid communication with the arterial and venous blood lines, and which dialysate side is in fluid communication with a dialysis fluid source comprising 2-8 mM citrate and 1-5 mM total calcium;
- and
- a pre-filter infusion line for the CRRT apparatus and connected to the arterial blood line upstream the filter and connected to an anticoagulation fluid source containing at least 8 mM citrate to be infused into the blood stream in the arterial blood line.
A system for regional citrate anticoagulation in an extracorporeal blood circuit for continuous renal replacement therapy (CRRT), the system comprising an arterial blood line configured to be connected to a vascular access for withdrawing blood from a patient and a venous blood line configured to be connected to the vascular access for returning blood to the patient, the system comprising:
- a filter for a CRRT blood treatment apparatus, the filter including a dialysate side and a blood side, which blood side is in fluid communication with the arterial and venous blood lines;
- a first pre-filter infusion line for the CRRT blood treatment apparatus and connected to the arterial blood line upstream the filter and connected to an anticoagulation fluid source containing at least 8 mM citrate to be infused into the blood stream in the arterial blood line;
- and
- a second pre-filter infusion line for the CRRT blood treatment apparatus and connected to the arterial blood line upstream the filter and connected to an infusion fluid source comprising 2-8 mM citrate and 1-5 mM total calcium to be infused into the blood stream in the arterial blood line.
A method of performing regional citrate anticoagulant dialysis of a patient's blood during continuous renal replacement therapy (CRRT), the method comprising:
- a) flowing blood from and back to the patient through a CRRT extracorporeal dialysis circuit including a dialyzer having semi-permeable dialysis membranes and a dialysate chamber surrounding the membranes;
- b) flowing a dialysis fluid containing calcium and citrate through the dialysate chamber of the dialyzer, wherein the dialysis fluid comprises 2-8 mM citrate and 1-5 mM total calcium;
- c) introducing a citrate containing anticoagulation fluid into the blood upstream of the dialyzer in a sufficient amount to reduce clotting of the patient's blood in the CRRT extracorporeal dialysis circuit, wherein the citrate containing anticoagulation fluid comprises at least 8 mM citrate;
- and
- d) infusing blood, which has passed through the dialyzer, into the patient.
A method of performing regional citrate anticoagulant dialysis of a patient's blood during continuous renal replacement therapy (CRRT), the system comprising:
- a) flowing blood from and back to the patient through a CRRT extracorporeal dialysis circuit including a dialyzer having a semi-permeable dialysis membrane and a dialysate side adjacent the membrane;
- b) flowing a dialysis fluid comprising 1-5 mM total calcium and 2-8 mM citrate through the dialysate side of the dialyzer;
- and
- c) introducing a citrate containing anticoagulation fluid comprising at least 8 mM citrate into the patient's blood upstream of the dialyzer in a sufficient amount to reduce clotting of the patient's blood in the CRRT extracorporeal dialysis circuit, whereby the patient's blood is dialyzed.
Dependencies are inferred from the claim text.