Apparatus for the aerosolization of large volumes of dry powder

A system for dosing and aerosolization of aerosolizable material, the system comprising:

• a body with an aerosolization channel having a distal attachment portion connectable to a source of carrier gas which provides pressure pulses of the gas to the aerosolization channel and a proximal attachment portion for outputting aerosolized material towards a patient;
• a reservoir for receiving aerosolizable material, the reservoir comprising at least one wall and being connected in a gas-tight manner to the body and in fluid connection with the aerosolization channel;
• a funnel portion tapered towards the aerosolization channel provided in the body between the reservoir and the aerosolization channel;
• an additional piece of pathway for aerosol to traverse configured to introduce expansion space for the pulsed gas stream and thus allow the pressure pulse of the gas arranged to carry the aerosol to the patient to dampen, the additional piece of pathway being a first hollow spacer comprising a distal portion having at least one inner wall tapered towards the proximal attachment portion, and a proximal portion having at least one inner wall and configured to taper towards the patient, with a central cylindrical portion therebetween haying at least one inner wall, and the additional piece of pathway further being connected to the proximal attachment portion;
• and
• a compensation tubing provided between an interior of the first hollow spacer and an interior of the funnel portion,
• wherein at least one wall of the funnel portion and the at least one inner wall of the distal portion, of the central portion and/or the proximal portion of the first hollow spacer comprise self-exciting membranes that can be put into oscillation by the pressure pulses,
• and wherein corresponding spaces are provided between such self-exciting membranes and an outer wall.