Solid forms of ceftolozane
AssigneeCalixa Therapeutics, Inc.
InventorsYou Seok Hwang, Nicole Miller Damour, Lisa Duong, Valdas Jurkauskas, Kristos Adrian Moshos, Sanjay Mudur, Asli Ovat, Joseph Terracciano, Jason Woertink
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Abstract
Novel solid forms of ceftolozane are described, as well as methods for the preparation and use of these solid forms.
Claims30
Solid Form 2 of ceftolozane sulfate that produces an X-ray powder diffraction (XRPD) pattern having diffractions at angles (2 theta±0.2) of 4.4, 8.8. 11.0, 14.9, and 17.7.
A pharmaceutical composition comprising the solid form of ceftolozane sulfate designated as ceftolozane sulfate Form 2 that produces an X-ray powder diffraction (XRPD) pattern having diffractions at angles (2 theta±0.2) of 4.4, 8.8. 11.0, 14.9, and 17.7.
A pharmaceutical composition comprising a lyophilized ceftolozane composition obtained by a process comprising the steps of:
- a. combining the ceftolozane sulfate in a solid form designated as ceftolozane sulfate Form 2 that produces an X-ray powder diffraction (XRPD) pattern having diffractions at angles (2 theta±0.2) of 4.4, 8.8, 11.0, 14.9, and 17.7, with water, sodium chloride and L-arginine to form an aqueous solution;
- and
- b. lyophilizing the aqueous solution to form the lyophilized ceftolozane composition comprising ceftolozane sulfate.
A pharmaceutical composition comprising a lyophilized ceftolozane composition obtained by a process comprising the steps of:
- a. combining the ceftolozane sulfate of solid Form 2 that produces an X-ray powder diffraction (XRPD) pattern having diffractions at angles (2 theta±0.2) of 4.4, 8.8. 11.0, 14.9, and 17.7 with water to form an aqueous solution;
- and
- b. lyophilizing the aqueous solution to form the lyophilized ceftolozane composition comprising ceftolozane sulfate.
Dependencies are inferred from the claim text.