Multiple antigen delivery system using hepatitis E virus-like particle
AssigneesThe Regents of the University of California, National Institute of Infectious Disease, Tsukuba Primate Research Center, National Institue of Biomedical Innovation
InventorsR. Holland Cheng, Li Xing, Tatsuo Miyamura, Yasuhiro Yasutomi, Tian-Cheng Li, Naokazu Takeda
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Abstract
This invention provides a peptide/nucleic acid composition for oral/mucosal, dual-modal activation of immune protection systems.
Claims16
A composition comprising:
- an HEV capsid protein comprising a portion of an HEV ORF 2 protein and a heterologous peptide, wherein the heterologous peptide is inserted into the portion of HEV ORF 2 within a pre-selected region corresponding to residues 483-490, residues 530-535, residues 554-561, residues 573-577, or residues 582-593, or residues 601-613 of SEQ ID NO:1;
- and
- a heterologous nucleic acid encapsulated in a chimeric HEV virus-like particle (VLP) formed by the HEV capsid protein.
An HEV capsid protein, comprising a portion of an HEV ORF 2 protein and a heterologous peptide inserted into the portion of the HEV ORF 2 within a pre-selected region of residues corresponding to residues 483-490, residues 530-535, residues 554-561, residues 573-577, residues 582-593, or residues 601-613 of SEQ ID NO:1, wherein the HEV capsid protein forms an HEV VLP.
Dependencies are inferred from the claim text.