Amino acid derivatives and absorbable polymers therefrom
AssigneeBezwada Biomedical, LLC
InventorRao S. Bezwada
Life of this patent
Estimating the term…
Abstract
The present invention relates to the discovery of new class of hydrolysable amino acid derivatives and absorbable polyester amides, polyamides, polyepoxides, polyureas and polyurethanes prepared therefrom. The resultant absorbable polymers are useful for drug delivery, tissue engineering, tissue adhesives, adhesion prevention, bone wax formulations, medical device coatings, stents, stent coatings, highly porous foams, reticulated foams, wound care, cardiovascular applications, orthopedic devices, surface modifying agents and other implantable medical devices. In addition, these absorbable polymers should have a controlled degradation profile.
Claims10
An isocyanate of Formula (ZZ):
- Wherein:
- Each X is independently selected from:
- —OCH2C(═O)—;
- —OCH(CH3)C(═O)—;
- —OCH2CH2OCH2C(═O)—;
- —OCH2CH2CH2CH2CH2C(═O)—;
- —O(CH2)yC(═O)—, where y is one of the numbers 2, 3, 4, and 6-24;
- or
- —O(CH2CH2O)mCH2C(═O)—;
- where m is integer between 2-24 inclusive;
- wherein p is independently selected from 1 to 6 inclusive;
- Each Y is independently selected from:
- —C(═O)CH2O—;
- —C(═O)CH(CH3)O—;
- —C(═O)CH2OCH2CH2O—;
- —C(═O)CH2CH2CH2CH2CH2O—;
- —C(═O)(CH2)yO—, where y is one of the numbers 2, 3, 4, and 6-24;
- or
- —C(═O)(CH2CH2O)mCH2O—;
- where m is integer between 2-24 inclusive;
- wherein X and Y are oriented as shown above;
- and
- R′ is selected from alkyl, aryl and arylalkyl, with alkyl chains containing a primary (long) chain of 2 up to 24 chain atoms, alternatively, the primary chain —CH2— groups are substituted with —O—, or —S— to form ester or thioester groups, and alternatively, the primary chain and aryl can be substituted with lower alkyl group(s).
Dependencies are inferred from the claim text.