Therapeutic compositions comprising imidazole and imidazolium compounds

A method of treating pain, comprising administering a dosage form to a mammal in need thereof, comprising:

• zoledronic acid,
• and

A method of treating a disease or condition related to pain, bone, or cancer comprising administering an oral dosage form to a mammal in need thereof, comprising:

• zoledronic acid,
• and
• wherein the disease or condition related to pain, bone or cancer is inflammatory pain, arthritis pain, complex regional pain syndrome, lumbosacral pain, musculoskeletal pain, neuropathic pain, chronic pain, cancer-related pain, acute pain, postoperative pain, low back pain, rheumatoid arthritis, juvenile rheumatoid arthritis, osteoarthritis, erosive osteoarthritis, a sero-negative or non-rheumatoid arthropathy, non-articular rheumatism, a peri-articular disorder, axial spondyloarthritis, ankylosing spondylitis, Paget's disease of bone, fibrous dysplasia, SAPHO syndrome, transient osteoarthritis of the hip, pain associated with vertebral crush fractures, osteoporosis, neuropathic pain, diabetic peripheral neuropathy, post-herpetic neuralgia, trigeminal neuralgia, monoradiculopathies, phantom limb pain, central pain, cancer-related pain, lumbar nerve root compression, spinal cord injury, post-stroke pain, central multiple sclerosis pain, HIV-associated neuropathy, radio-therapy associated neuropathy, chemo-therapy associated neuropathy, or a combination thereof.