System and method for satellite drug delivery

#Administration of bioactive agents in conjunction with medical procedures is common practice in the surgical arts. Bioactive agents have been applied during procedures as solutions sprayed onto tissue or as coatings on medical devices.

#Use of bioactive agents during surgical procedures allows for local application of medicaments. This may enable the use of bioactive agents that may not be absorbed when administered orally or parenterally. Hemostatic agents may be used to reduce bleeding in situ, analgesics may be applied to the injured tissue, antibiotics may be used to prevent infection at the site of incision, and anti-adhesion agents may prevent scar tissue formation around an implant.

#Processes used to attach bioactive agents to a medical device, such as surface modification by methods such as plasma treatment, silane coupling treatment and acid sensitization, cell immobilization, plasma grafting, and the like are often complicated and costly. Often bioactive agents may be applied as a coating to specific medical devices. Therefore, other devices at the tissue site may not benefit from local delivery of a bioactive agent from the coated medical device.

#The foregoing objects and advantages of the disclosure will become more apparent from the reading of the following description in connection with the accompanying drawings, in which:

#FIG. 1A is a perspective view of an implantable repository according to an embodiment of the disclosure;

#FIG. 1B is a perspective view of an implantable repository according to an embodiment of the disclosure;

#The present disclosure provides for an implantable repository for delivering a bioactive agent to tissue and methods of using the same. The present disclosure further allows for use of any bioactive agent or group of bioactive agents with various types of wound closure devices.

#In accordance with the present disclosure, an implantable repository may be a part of a satellite drug delivery system (SDDS). In embodiments, the SDDS may include a repository, a receptacle, a capsule or any other suitable repository having a housing. The housing of the implantable repositories may include a bioactive agent contained or embedded within the housing. The repository may also include an attachment member such as a loop or a hook coupled to or extending from the housing. Medical instruments for delivering the repositories are also provided. The implantable repositories may also be coupled via a medical device, e.g., a fastener, which may couple to the attachment member for transport and/or attachment to tissue.

#The term “wound closure device” refers to any device suitable for joining together two or more tissue structures, such as sutures, adhesives, staples, clips, fasteners, tacks, and the like. The term “medical device” refers to any structure formed of a biocompatible material that is suitable for being attached or implanted into tissue, body organs or lumens, including, but not limited to, wound closure devices, films, foams, sheets, pledgets, tissue grafts (e.g., vascular, skin, bone, etc.), stents, scaffolds, meshes, buttresses, and the like. In the drawings and in the description that follows, the term “proximal,” refers to an end of an instrument that is closer to the user, while the term “distal” refers to the end of the instrument that is further from the user.