Method and apparatus for therapies of the cardiovascular and cardiorenal system
AssigneeMedtronic, Inc.
InventorsMustafa Karamanoglu, Vincent E Splett
Life of this patent
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Abstract
A system and method for controlling respiration depth or respiration rate is provided. A bipolar pair of a plurality of electrodes is selected in a location for stimulating a phrenic nerve. Electrical stimulation is delivered through a medical electrical lead electrode proximate phrenic nerve tissue. Modulating respiration is elicited in response to electrical stimulation of the phrenic nerve.
Claims41
A method of controlling respiration depth or respiration rate through an implanted medical electrical lead having an electrode for pacing and sensing, the method comprising:
- delivering electrical stimulation through an electrode proximate phrenic nerve tissue, and
- eliciting modulating respiration in response to electrical stimulation of the phrenic nerve, the modulating respiration asynchronously modifies intrinsic respiration,
- wherein glomerular filtration rate (GFR) is improved by about 10% compared to another GFR before any phrenic nerve stimulation has occurred.
A method of controlling respiration depth or respiration rate through an implanted medical electrical lead having an electrode for pacing and sensing, the method comprising:
- delivering electrical stimulation through an electrode proximate phrenic nerve tissue, and
- eliciting modulating respiration in response to electrical stimulation of the phrenic nerve, the modulating respiration asynchronously modifies intrinsic respiration, wherein GFR is improved by about 15% compared to another GFR of before any phrenic nerve stimulation has occurred.
A stimulator system comprising:
- a phrenic nerve tissue electrode and a physiological electrode, spatially separated from one another and all coupled to an implantable pulse generator, the implantable pulse generator comprising:
- delivering electrical stimulation through an electrode proximate phrenic nerve tissue, the delivery of electrical stimulation is timed without sensed respiration data, wherein glomerular filtration rate (GFR) is improved by about 10% compared to another GFR before any phrenic nerve stimulation has occurred.
A stimulator system comprising:
- a phrenic nerve tissue electrode and a physiological electrode, spatially separated from one another and all coupled to an implantable pulse generator, the implantable pulse generator comprising:
- means for delivering electrical stimulation through an electrode proximate phrenic nerve tissue, and
- means for eliciting modulating respiration in response to electrical stimulation of the phrenic nerve, the modulating respiration asynchronously modifies intrinsic respiration, wherein glomerular filtration rate (GFR) is improved by about 10% compared to another GFR before any phrenic nerve stimulation has occurred.
A method of controlling respiration depth or respiration rate through an implanted medical electrical lead having an electrode for pacing and sensing, the method comprising:
- delivering electrical stimulation through an electrode proximate phrenic nerve tissue, the delivery of electrical stimulation is timed without sensed respiration data;
- determining whether a termination condition is detected;
- and terminating phrenic nerve stimulation in response to detecting the termination condition.
A method of controlling respiration depth or respiration rate through an implanted electrical lead having an electrode for pacing and sensing, the method comprising:
- determining whether to initiate stimulation of the phrenic nerve based on a predetermined initiation event;
- in response to determining whether to initiate stimulation, delivering electrical stimulation through an electrode proximate phrenic nerve tissue,
- eliciting modulating respiration in response to electrical stimulation of the phrenic nerve, the modulating respiration asynchronously modifies intrinsic respiration;
- detecting a cardiovascular parameter within a predetermined range;
- and
- terminating electrical stimulation in response to detecting the cardiovascular parameter within the predetermined range wherein glomerular filtration rate (GFR) is improved by about 10% compared to another GFR before any phrenic nerve stimulation has occurred.
A neurostimulator system comprising:
- a pulse generator;
- a medical electrical lead having one or more electrodes, the medical electrical lead connected to the pulse generator;
- means for stimulating phrenic nerve tissue;
- modulating respiration in response to stimulating phrenic nerve stimulation;
- and
- means for terminating phrenic nerve stimulation without using respiration data, wherein glomerular filtration rate (GFR) is improved by about 10% compared to another GFR before any phrenic nerve stimulation has occurred.
A method of controlling ventilation depth or ventilation rate through an implanted electrical lead having an electrode for pacing and sensing, the method comprising:
- determining whether to initiate stimulation of the phrenic nerve based on a predetermined initiation event;
- in response to determining whether to initiate stimulation, delivering electrical stimulation through an electrode proximate phrenic nerve tissue,
- eliciting modulating ventilation in response to electrical stimulation of the phrenic nerve, the modulating ventilation asynchronously modifies intrinsic ventilation;
- detecting a cardiovascular parameter within a predetermined range;
- and terminating electrical stimulation in response to detecting the cardiovascular parameter,
- wherein glomerular filtration rate (GFR) is improved by about 10% compared to another GFR before any phrenic nerve stimulation has occurred.
Dependencies are inferred from the claim text.