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US 8,895,780 B2Granted
Process for preparing N-H or N-alkyl 2-propynamide
AssigneeBoehringer Ingelheim International GmbH
InventorsDa Deng, Juncheng Zheng
Life of this patent
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Abstract
Disclosed is a method for the synthesis of N—H or N-alkyl 2-propynamides useful as intermediate in the manufacture of pharmaceutically active ingredients.
Claims6
A method of preparing N—H or N-alkyl 2-propynamides of formula (I)
- wherein
- R1 is hydrogen or C1-4-alkyl,
- said process comprising reacting a propiolic acid ester of formula (II)
- wherein
- R2 is C1-2-alkyl,
- with an amine of the formula (III)
- wherein
- R1 is defined as in formula (I),
- in water, and at a reaction temperature from of about −10° C. to about 10° C. to form a compound of formula (I).
6 more elements
Dependencies are inferred from the claim text.