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US 8,895,762 B2Granted
Process for the preparation of sulfamide derivatives
AssigneeJanssen Pharmaceutica NV
InventorsStefan Horns, Roger Faessler
Life of this patent
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Abstract
The present invention is directed to an improved process for the preparation of sulfamide derivatives.
Claims9
A process for the preparation of a compound of formula (I)
- wherein
- R1 and R2 are each independently selected from the group consisting of hydrogen and lower alkyl;
- R4 is selected from the group consisting of hydrogen and lower alkyl;
- a is an integer from 1 to 2;
- is
- wherein b is an integer from 0 to 4;
- and wherein each R5 is independently selected from the group consisting of halogen and lower alkyl;
- and pharmaceutically acceptable salts thereof;
- comprising
- reacting a compound of formula (V-S) with a compound of formula (VI-S);
- in the presence of a acid organic base buffer system in water or an aqueous solvent system;
- at reflux temperature;
- to yield the corresponding compound of formula (I-S) and ammonia.
10 more elements
A process for the preparation of a compound of formula (I-S)
- or a pharmaceutically acceptable salt thereof;
- comprising
- reacting a compound of formula (V-S) with a compound of formula (VI-S);
- in the presence of a buffer system;
- in water or an aqueous solvent system;
- at reflux temperature;
- to yield the corresponding compound of formula (I-S) and ammonia.
4 more elements
Dependencies are inferred from the claim text.