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US 8,895,759 B2Granted
Intermediates useful in the preparation of maleimide functionalized polymers
AssigneeNektar Therapeutics
InventorsSamuel P. McManus, Antoni Kozlowski, Tracy L. Hutchison, Brian Bray, Xiaoming Shen
Life of this patent
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Abstract
Methods for forming maleimide functionalized polymers are provided. In one such embodiment, a maleimide functionalized polymer is prepared in a method that includes a step of carrying out a reverse Diels-Alder reaction. Intermediates useful in the methods, as well as methods for preparing the intermediates, are also provided. Also provided are polymeric reagents, methods of using polymeric reagents, compounds and conjugates.
Claims4
A compound of the following structure:
- wherein n′ is 2 to about 10.
Dependencies are inferred from the claim text.