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US 8,895,753 B2Granted
S1P receptor modulating agent
AssigneeMeiji Seika Pharma Co., Ltd.
InventorsSatoshi Yoshida, Tomohisa Ninomiya
Life of this patent
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Abstract
An object of the present invention is to provide a compound having a modulating activity at an S1P receptor which is useful for preventing and treating autoimmune diseases, allergic diseases, and the like. According to the present invention, a compound represented by formula (I) or a pharmaceutically acceptable salt thereof is provided.
Claims7
A compound represented by the following formula (I):
- wherein
- A represents a 4- to 7-membered cyclic amine;
- m represents an integer of 0 to 5;
- n represents an integer of 1 to 3;
- p represents an integer of 1 to 3;
- q represents an integer of 0 to 4;
- R1 represents C1-10 alkyl, C1-10 alkoxy, phenyl, phenoxy, phenyl C1-3 alkyloxy, a halogen atom, halogeno C1-3 alkyl, or cyano (when m is 2 or more, R1 may be each independently identical or different);
- R2 represents COOH, COOR6, CONR7R8, or tetrazolyl (when n is 2 or more, R2 may be each independently identical or different);
- R3 represents a hydrogen atom or C1-6 alkyl;
- R4 represents a hydrogen atom or C1-6 alkyl;
- or R3 and R4 may together form an oxo group (when p is 2 or more, R3 and R4 may be each independently identical or different);
- R5 represents C1-6 alkyl, C1-6 alkoxy, a halogen atom, halogeno C1-3 alkyl, cyano, hydroxyl, or amino (when q is 2 or more, R5 may be each independently identical or different);
- R6 represents C1-10 alkyl;
- and
- R7 and R8 each independently represent a hydrogen atom or C1-10 alkyl, or a pharmaceutically acceptable salt thereof.
12 more elements
Dependencies are inferred from the claim text.