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US 8,895,748 B2Granted
Synthesis for thiazolidinedione compounds
AssigneeMetabolic Solutions Development Company, LLC
InventorsSteven P. Tanis, Timothy Parker, Robert C. Gadwood, James R. Zeller, Gerald D. Artman, III, Scott D. Larsen
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Abstract
The present invention provides novel methods for synthesizing PPARγ sparing compounds, e.g., thiazolidinediones, that are useful for preventing and/or treating metabolic disorders such as diabetes, obesity, hypertension, and inflammatory diseases.
Claims38
A method for preparing a compound of Formula I:
- or a pharmaceutically acceptable salt thereof, wherein
- Each of R1 and R2 is independently selected from H, halo, aliphatic, and alkoxy,
- wherein the aliphatic or alkoxy is optionally substituted with 1-3 of halo;
- comprising the step of:
- converting a compound of Formula 2A to a compound of Formula I
- wherein R3 is hydrogen or an optionally substituted C1-6 alkyl.
3 more elements
Dependencies are inferred from the claim text.