Method and substances for preparation of N-substituted pyridinium compounds

A method for synthesis of an N-substituted pyridinium compound comprising the steps of:

• a) providing a Zincke salt according to any of following Formulas (IV)-(VII) and having at least one counter ion, selected from the group consisting of:
• Cl, Br, Tosylate, Mesylate, and Triflate:
• wherein
• X is O or S,
• R1 is methyl, ethyl, O-methyl, O-ethyl, NH2, N-dimethyl, N-diethyl, and
• R2 is NH2;
• wherein
• X is O or S,
• R1 is methyl, ethyl, O-methyl, O-ethyl, NH2, N-dimethyl, N-diethyl, and
• R2 is NH2 or Cl;
• wherein
• X is O or S,
• R1 is methyl, ethyl, O-methyl, O-ethyl, NH2, N-dimethyl, N-diethyl, and
• R2 and R3 independently are O—C1-C3 alkyl or NH2;
• wherein
• X is O or S,
• R1 is methyl, ethyl, O-methyl, O-ethyl, NH2, N-dimethyl, N-diethyl, and
• R2 and R3 independently are O—C1-C3 alkyl and R7=H or Cl;
• b) reacting the Zincke salt of step (a) with a primary amine of Formula II:
• wherein
• the primary amine of Formula II is selected from the group consisting of:
• an alkyl amine, an alkyenyl amine, a heterocycloalkyl amine, an aryl amine, a heteroaryl amine, an amino alcohol, an amino acid, a furanoxylamine, or a cyclopentylamine,
• c) obtaining, an N-substituted pyridinium compound of Formula III:
• having a counter ion,
• wherein X is O or S,
• R1, is methyl, ethyl, O-methyl, O-ethyl, NH2, N-dimethyl, N-diethyl;
• and
• R6 is selected from the group consisting of:
• alkyl, alkyenyl, heterocycloalkyl, aryl, heteroaryl, hydroxyalkyl, carboxylic acid, a furanoxyl, or cyclopentyl.