Compounds that suppress cancer cells and exhibit antitumor activity
AssigneesUniversity of Central Florida Research Foundation, Inc., The Governing Council of the University of Toronto
InventorsJames Turkson, Patrick Gunning
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Abstract
The present invention provides compounds S3I-201.1066 (Formula 1) and S3I-201.2096 (Formula 2) as selective Stat3 binding agents that block Stat3 association with cognate receptor pTyr motifs, Stat3 phosphorylation and nuclear translocation, Stat3 transcriptional function, and consequently induced Stat3-specific antitumor cell effects in vitro and antitumor response in vivo.
Claims20
A method effective to inhibit a cancer cell, comprising the step of contacting the cell with a compound and salts thereof according to Formula 1 or Formula 2:
- thereby inhibiting the cancer cell.
A method effective to inhibit Stat3 activity in a cell, comprising the step of contacting the cell with a compound and salts thereof according to Formula 1 or Formula 2:
- thereby inhibiting Stat3 in the cell.
A method effective to down-regulate the expression of Stat3-regulated genes in a cell, comprising the step of contacting the cell with a compound and salts thereof according to Formula 1 or Formula 2:
- thereby down-regulating Stat3 regulated genes in the cell.
Dependencies are inferred from the claim text.