Bicyclic heterocyclic compounds as FGFR inhibitors

A compound of formula (Id):

• wherein
• J and L are independently selected from carbon and nitrogen;
• R5 represents hydrogen, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, alkanol, C1-6 alkanol, haloC1-6 alkyl, —(CH2)n—NRxRy, —(CH2)s—COORz, or —(CH2)n—O—(CH2)m—OH, wherein said C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl groups may be optionally substituted by one or more Ra groups;
• Rx, Ry and Rz independently represent hydrogen, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 alkanol, —COOC1-6 alkyl, hydroxy, C1-6 alkoxy, haloC1-6 alkyl, —CO—(CH2)n—C1-6 alkoxy, C1-6 alkylamino, C3-8 cycloalkyl or C3-8 cycloalkenyl;
• R2 and R6 independently represent halogen, hydrogen, C1-6 alkyl, C1-6 alkoxy, C2-6 alkenyl, C2-6 alkynyl, —C≡N, C3-8 cycloalkyl, C3-8 cycloalkenyl, —NHSO2Rw, —CH═N—ORw, an aryl or heterocyclyl group wherein said aryl and heterocyclyl groups may be optionally substituted by one or more Rb groups, and said C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl may be optionally substituted by one or more Rb′ groups, provided that R2 and R6 do not both represent hydrogen;
• Rw represents hydrogen or C1-6 alkyl;
• Ra represents halogen, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-8 cycloalkyl, C3-8 cycloalkenyl, —ORx, —(CH2)n—O—C1-6 alkyl, —O—(CH2)n—ORx, haloC1-6 alkyl, haloC1-6 alkoxy, C1-6 alkanol, ═O, ═S, nitro, Si(Rx)4, —(CH2)s—CN, —SO—Rx, —SO2—Rx, —CORx, —(CRxRy)s—COORz, —(CH2)s—CONRXRy, —(CH2)s—NRxRy, —(CH2)s—NRxCORy, —(CH2)s—NRxSO2—Ry, —(CH2)s—NH—SO2—NRxRy, —OCONRxRy, —(CH2)s—NRxCO2Ry, —O—(CH2)s—CRxRy—(CH2)t—ORz or —(CH2)s—SO2NRxRy groups;
• q represents an integer from 0 to 3;
• Rb represents an Ra group or a —Y-carbocyclyl or —Z-heterocyclyl group wherein said carbocyclyl and heterocyclyl groups may be optionally substituted by one or more Ra groups;
• Y and Z independently represent a bond, —CO—(CH2)s—, —COO—, —(CH2)n—, —NRx—(CH2)n—, —(CH2)n—NRx—, —CONRx—, —NRxCO—, —SO2NRx—, —NRxSO2—, —NRxCONRy—, —NRxCSNRy—, —O—(CH2)s—, —(CH2)s—O—, S—, —SO— or —(CH2)s—SO2—;
• Rb′ represents an Ra′ group or a —Y-carbocyclyl or —Z-heterocyclyl group wherein said carbocyclyl and heterocyclyl groups may be optionally substituted by one or more Ra groups;
• Ra′ represents halogen, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-8 cycloalkyl, C3-8 cycloalkenyl, —(CH2)n—O—C1-6 alkyl, —O—(CH2)n—ORx, haloC1-6 alkyl, haloC1-6 alkoxy, C1-6 alkanol, ═S, nitro, Si(Rx)4, —(CH2)s—CN, —S—Rx, —SO—Rx, —SO2—Rx, —CORx, —(CRxRy)s—COORz, —(CH2)s—CONRxRy, —(CH2)s—NRxRy, —(CH2)s—NRxCORy, —(CH2)s—NRxSO2—Ry, —(CH2)s—NH—SO2—NRxRy, —OCONRxRy, —(CH2)s—NRxCO2Ry, —O—(CH2)s—CRxRy—(CH2)t—ORz or —(CH2)s—SO2NRxRy groups;
• m and n independently represent an integer from 1-4;
• s and t independently represent an integer from 0-4;
• or a pharmaceutically acceptable salt or solvate thereof,
• with the proviso that the compound of formula (Id) is not:
• N-{2-fluoro-4-[6-(1-trityl-1H-4-pyrazolyl)imidazo[1,2-a]pyridine-3-yl]phenyl}-N′-isopropyl urea;
• or
• N-{2-fluoro-4-[6-(1H-4-pyrazolyl)imidazo[1,2-a]pyridin-3-yl]phenyl}-N′-isopropylurea.