Synthesis of substituted 2-nitromalonaldehyde intermediates toward the preparation of polyaza-adamantanes

An acyclic intermediate compound having a structure of Formula I:

• wherein each R represents a primary alkyl, which is selected from one of an acetyl, a formyl, and an ally moiety, and
• wherein the acyclic intermediate compound is a bis(N-acetylamine) of 2-nitromalonaldehyde, or a pharmaceutically acceptable salt thereof.

An acyclic intermediate compound having a structure of Formula I:

• wherein each R represents a primary alkyl, which is selected from one of an acetyl, a formyl, and an allyl moiety, and
• wherein the acyclic intermediate compound is a bis(N-formylimine) of 2 nitromalonaldehyde, or a pharmaceutically acceptable salt thereof.

An acyclic intermediate compound having a structure of Formula I:

• wherein each R represents a primary alkyl, which is selected from one of an acetyl, a formyl, and allyl moiety, and wherein the acyclic intermediate compound is a bis(N-allylimine) of 2-nitromalonaldehyde, or a pharmaceutically acceptable salt thereof.

A method for preparing an acyclic intermediate compound having an arylalkyl moiety, comprising:

• reacting sodium nitromalonaldehyde monohydrate with primary arylalkylamines in aqueous methanol with acidic catalysis for forming at least one acyclic intermediate.

An acyclic intermediate compound having a structure of Formula I:

• wherein each R represents a primary arylalkyl moiety where said R is an alkoxybenzyl;
• or a pharmaceutically acceptable salt thereof.