Back to results
US 8,895,735 B2Granted
Preparation process of (6R)-tetrahydrobiopterin hydrochloride
AssigneeInnopharmax, Inc.
InventorsZhen Wang, Dongbing Zhao, Weida Wang, Jingbo Lan, Jinsong You
Life of this patent
Estimating the term…
Abstract
A preparation process of (6R)-tetrahydrobiopterin hydrochloride is provided, which comprises hydrogenating L-biopterin in the presence of a catalyst of Pt group metal in the basic substrate containing solvent, potassium hydroxide and potassium dihydrogen phosphate to obtain (6R)-tetrahydrobiopterin hydrochloride, wherein the pH value of the basic substrate is controlled by potassium hydroxide and potassium dihydrogen phosphate in the range of about 10 to about 13.
Claims8
A preparation process of (6R)-tetrahydrobiopterin hydrochloride, comprising
- hydrogenation of L-biopterin in the presence of a catalyst of a Pt group metal in a basic substrate containing a solvent, potassium hydroxide, and potassium dihydrogen phosphate to directly obtain (6R)-tetrahydrobiopterin hydrochloride, wherein the basic substrate is of a pH value, which is controlled by potassium hydroxide and potassium dihydrogen phosphate, in the range of about 10 to about 13.
Dependencies are inferred from the claim text.