US 8,895,725 B2 · Use of 9, 10-anthraquinone compounds

Abstract

Use of 9,10-anthraquinone compounds of formula (I) or pharmaceutical salts thereof or plant extracts containing said compounds in the preparation of anti-HCV medicaments is disclosed, in which Y1 are Y2 are independently hydrogen, hydroxyl or groups of formula (II); and R1, R2, R3, R4, R5 and R6 are independently hydrogen, hydroxyl, carboxyl, cyano group, nitro group, groups of formula (III) or groups selected from those substituted or unsubstituted groups: amino, C1-C6 aliphatic hydrocarbon, C3-C7 cyclic aliphatic hydrocarbon, C1-C6 alkoxy, C2-C7 carbalkoxy, C1-C4 acyloxy, C6-C20 aryl, or 5 to 7 members heterocyclic or benzoheterocyclic thereof; or R5 and R6 form the group of formula (IV). The compounds of present invention are cheap, safe and effective because that they mostly come from traditional Chinese medicines and have better anti-HCV effects and lighter side effects.

Claims12

Dependent claims

A method of treating a patient in need of a medicament for anti-hepatitis C virus, comprising administering to the patient a medicament comprising an effective amount of a 9,10-anthraquinone of Formula I:

or a pharmaceutically acceptable salt thereof or a plant extract thereof:
wherein Y1 and Y2 are independently hydrogen, hydroxyl or a group as shown in Formula II;
R1, R2, R3, R4, R5, and R6, are independently hydrogen, hydroxyl, carboxyl, cyano, nitryl, a group as shown in Formula III or one of the following groups with one or more substituent groups or unsubstituted;
amino, C1˜C6 chain hydrocarbyl, C3-˜C7 cyclic aliphatic hydrocarbyl, C1˜C6 alkoxy, C2˜C7 alkoxy carbonyl, C1˜C4 acyloxy, C6˜C20 aryl or 5˜7 members heterocyclic ring or benzohetercyclic ring thereof, wherein the one or more substituent groups are one or more selected from the group consisting of halogen, C1˜C6 chain hydrocarbyl, cyano, nitryl, amino, hydroxyl, carboxyl, C1˜C4 alkoxy, mercapto, C1˜C4 acyloxy and C6˜C20 aryl;
or R5 and R6 form a ring as shown in Formula IV, with the proviso that the 9,10-anthraquinone of formula I excludes emodin, aloe-emodin, and daunorubicin.

2 more elements

Dependencies are inferred from the claim text.

Use of 9, 10-anthraquinone compounds

Life of this patent

Use of 9, 10-anthraquinone compounds

Life of this patent

Abstract

Claims12