S100B mini-promoters

An isolated polynucleotide comprising

• an S100B regulatory element having at least 95% sequence identity to SEQ ID NO:2 wherein the sequence elements at SEQ ID NO:2 residues 85-105;
• residues 141-160;
• residues 212-231;
• residues 317-344;
• residues 415-447;
• residues 495-514;
• residues 531-553;
• residues 562-582;
• residues 603-624;
• residues 651-710;
• residues 720-746;
• residues 806-829;
• residues 931-966;
• residues 1191-1210;
• residues 1245-1287;
• residues 1300-1341;
• residues 1350-1375;
• residues 1422-1445;
• residues 1548-1577;
• residues 1630-1658;
• residues 1708-1730;
• residues 1743-1783;
• residues 1786-1807;
• residues 1912-1938;
• residues 2088-2158;
• residues 2212-2231;
• and residues 2315-2341 are each conserved and present in said polynucleotide,
• operably joined to an S100B basal promoter having at least 95% sequence identity to SEQ iD NO:3 wherein the sequence elements at SEQ ID NO:3, residues 79-116;
• residues 246-285;
• residues 424-503;
• residues 562-585;
• residues 769-792;
• residues 825-844;
• residues 880-933;
• residues 949-968;
• residues 975-1146;
• residues 1154-1173;
• and residues 1192-1218 are each conserved and present in said polynucleotide,
• wherein the S100B regulatory element and the S100B basal promoter are joined through a non-native spacing of not more than 1 kb between the basal promoter and the regulatory element.