Biological products
AssigneeUCB Pharma S.A.
InventorsSimon Peter Tickle, Heather Margaret Ladyman
Life of this patent
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Abstract
There is disclosed antibody molecules containing at least one CDR derived from a mouse monoclonal antibody having specificity for human CD22. There is also disclosed a CDR grafted antibody wherein at least one of the CDRs is a modified CDR. Further disclosed are DNA sequences encoding the claims of the antibody molecules, vectors, transformed host cells and uses of the antibody molecules in the treatment of diseases mediated by cells expressing CD22.
Claims19
An isolated DNA encoding a murine anti-CD22 monoclonal antibody, wherein the variable domain of the light chain has the sequence given in SEQ ID NO:7 and the variable domain of the heavy chain has the sequence given in SEQ ID NO:8.
An isolated DNA encoding a chimeric antibody molecule, wherein the variable domain of the light chain has the sequence given in SEQ ID NO:
- 7 and the variable domain of the heavy chain has the sequence given in SEQ ID NO:8.
An isolated DNA encoding an antibody or fragment thereof comprising a light chain variable domain and a heavy chain variable domain, wherein the antibody or fragment thereof is expressed in a mammalian cell and wherein the light chain variable domain has a sequence set forth in SEQ ID NO:7 and the heavy chain variable domain has a sequence set forth in SEQ ID NO:8.
Dependencies are inferred from the claim text.