Clostridial neurotoxins with altered persistency
AssigneeMERZ PHARMA GmbH & CO. KGaA
InventorJurgen Frevert
Life of this patent
Estimating the term…
Abstract
The invention relates to a polypeptide comprising: (a) a HC-domain or fragment thereof of the neurotoxic component of a clostridial toxin; and (b) a first LC domain or fragment thereof of the neurotoxic component of a clostridial toxin; and (c) at least one further LC domain or fragment thereof of the neurotoxic component of a clostridial toxin wherein the first and the at least one further LC domain may be the same or different from each other, and wherein each of said fragments of said first and of said at least one further LC domain still exhibits proteolytic activity.
Claims5
A nucleic acid encoding a polypeptide comprising:
- (a) a heavy chain (HC) domain of a neurotoxic component of a clostridial toxin;
- (b) a first light chain (LC) domain of a neurotoxic component of a clostridial toxin;
- and
- (c) at least one further LC domain of a neurotoxic component of a clostridial toxin;
- wherein the domains are connected by a direct linkage via a covalent bond, a peptide-linker, a chemical linker, or a combination of two or more thereof, and wherein the first and at least one further LC domains may be the same or different from each other, and wherein each of the first and at least one further LC domains exhibit proteolytic activity.
Dependencies are inferred from the claim text.