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US 8,895,711 B2Granted
Mutated ACVR1 for diagnosis and treatment of Fibrodyplasia Ossificans Progressiva (FOP)
AssigneeThe Trustees of the University of Pennsylvania
InventorsFrederick S. Kaplan, Eileen M. Shore
Life of this patent
Estimating the term…
Abstract
This invention is directed to mutated Activin A type I receptor proteins (ACVR1) and isolated nucleic acids encoding same. The invention also relates to the use of mutated ACVR1 in the diagnosis and treatment of Fibrodysplasia Ossificans Progressiva (FOP).
Claims11
A molecular beacon nucleic acid comprising a stem and a loop and a detectable label, wherein the loop consists of at least 15 contiguous bases of SEQ ID NO:
- 34 or of at least 15 contiguous bases of the complement of SEQ ID NO:
- 34, wherein position 11 of SEQ ID NO:
- 34 is an A.
Dependencies are inferred from the claim text.