Antibodies against a proliferating inducing ligand (APRIL) and methods of use thereof
AssigneeBionovion Holding B.V.
InventorsJan Paul Medema, Hans Van Eenennaam, Marco Guadagnoli, Fiona Clare Kimberley, Uyen Truong Phan
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Abstract
The present invention relates to a binding compound which binds to human APRIL. More specifically the invention provides, compositions of anti-APRIL specific antibodies and methods to use such antibodies in modulating the biological activity APRIL, particularly in inflammatory diseases, inhibition of cell proliferation and cancer.
Claims14
An isolated antibody or antibody fragment which binds to human a proliferating inducing ligand (APRIL) comprising:
- a. an antibody heavy chain variable region comprising CDRs SEQ ID NOs:
- 9, 10, and 11;
- and
- b. an antibody light chain variable region comprising CDRs SEQ ID NOs:
- 12, 13, and 14,
- wherein the antibody or antibody fragment fully blocks the binding of APRIL with human transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI) and human B cell maturation antigen (BCMA).
An isolated antibody or antibody fragment which binds to human APRIL wherein the antibody or antibody fragment binds to an epitope having the amino acid sequence of SEQ ID NO:33 or SEQ ID NO:34.
Dependencies are inferred from the claim text.