Intravenous administration of tramadol
AssigneeRevogenex Ireland Ltd
InventorsS. George Kottayil, Jeffrey H. Ping
Life of this patent
Estimating the term…
Abstract
A method of treating pain, e.g., acute post-operative pain, by administering to a human patient(s) a therapeutically effective dose of tramadol intravenously over a prolonged time period is disclosed. In certain embodiments, the dose is intravenously administered in a time period from about 10 minutes to about 3 hours, preferably from about 10 minutes to about 30 minutes. In other embodiments, intravenous doses are administered at suitable time intervals over a time period from about 3 hours to 48 hours.
Claims65
A method of treating pain, comprising administering to a human patient a therapeutically effective dose of tramadol, or a pharmaceutically acceptable salt thereof, intravenously over a time period from 10 minutes to about 45 minutes.
A method for treating pain in humans, comprising providing a dose of tramadol or a pharmaceutically acceptable salt thereof in solution from about 1 ml to about 5 ml at a concentration from about 50 mg/ml to about 200 mg/ml;
- diluting the dose of tramadol in a volume of a pharmaceutically acceptable carrier for injection from about 50 ml to about 500 ml to provide a therapeutically effective unit dose of from about 50 mg to about 200 mg tramadol in said volume of pharmaceutically acceptable carrier for injection;
- administering the unit dose of tramadol intravenously over a time period from 10 minutes to about 45 minutes.
A method of treating acute pain, comprising administering to a human patient(s) a therapeutically effective dose of tramadol or a pharmaceutically acceptable salt thereof intravenously over a time period from 10 minutes to about 30 minutes such that a reduction in at least one side-effect associated with tramadol therapy is achieved.
A method of treating acute postoperative pain in human patients, comprising
- administering to a human patient intra-operatively at wound closure, or from first demand of analgesia postoperatively a therapeutically effective dose from about 50 mg to about 200 mg of tramadol intravenously over a time period from 10 minutes to about 30 minutes;
- administering further doses of intravenous tramadol at from about 2 to about 6 hour time intervals to treat pain in said patient for at least about 48 hours post-surgery, wherein each further dose of tramadol is administered intravenously over a time period from 10 minutes to about 30 minutes;
- and
- administering a therapeutically effective dose of an intravenous opioid analgesic which is not tramadol to the patient to treat the patient's pain.
Dependencies are inferred from the claim text.