Fluorosubstituted-(3R,4R,5S)-5-guanidino 4-acetamido-3-(pentan-3-yloxy)cyclohex-1-enecarboxylic acid compound, ester and use thereof
OwnerAlexandre Vasilievich Ivachtchenkoinventor
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Abstract
The present invention relates to novel neuraminidase activity inhibitors and use thereof for prophylaxis and treatment of influenza infection, that is to fluorosubstituted4-acetamido-5-guanidino-3-(pentan-3-yloxy)cyclohex-1-enecarboxylic acids and their esters of the general formula 1, pharmaceutically acceptable salts and/or hydrates thereof, wherein R is hydrogen, an optionally substituted C1-C5alkyl, C2-C5alkenyl or C2-C5alkynyl; Rf is CH2F or CHF2. A pharmaceutical composition is provided, a method for its preparation, as well as a method for prophylaxis and treatment of viral diseases.
Claims9
A fluorosubstituted (3R,4R,5S)-4-acylamido-5-guanidino-3-(pentan-3-yloxy)cyclohex-1-enecarboxylic acid compound of general formula 1, or a pharmaceutically acceptable salt or hydrate thereof,
- wherein:
- R is hydrogen, an optionally substituted C1-C5alkyl, C2-C5alkenyl or C2-C5alkynyl;
- Rf is CH2F or CHF2.
Dependencies are inferred from the claim text.