6-pyrazolylamido-3-substituted azabicyclo[3.1.0]hexane compounds as calcium channel inhibitors
AssigneeKorea Institute of Science and Technology
InventorsGhil Soo Nam, Kyung Il Choi, Ae Nim Pae, Seon Hee Seo, Hyun Ah Choo, Gyo Chang Keum, Jung Hyun Kim
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Abstract
The present invention relates to a 6-pyrazolylamido-3-substituted azabicyclo[3.1.0]hexane derivatives useful as calcium channel blockers, pharmaceutically acceptable salts thereof and medical use of the calcium channel inhibiting effect of the compounds for treatment of diseases.
Claims7
A compound selected from a group consisting of 6-pyrazolylamido-3-substituted azabicyclo[3.1.0]hexane derivatives represented by Formula 1 and pharmaceutically acceptable salts thereof:
- wherein
- —X—NH—Y— represents —C(O)NH(CH2)q- or —(CH2)qNHC(O)—;
- R1 represents C1-C6 alkyl;
- R2 represents C1-C6 alkyl,
- R3 represents hydrogen, C1-C6 alkyl or C1-C6 haloalkyl substituted with 1-6 halogen atom(s);
- and
- each of q, m and n represents an integer from 0 to 6.
A compound selected from:
- 3-[3-(3,3-dimethylbutyl)-3-azabicyclo[3.1.0]hexane-6-carboxamido]methyl-5-isobutyl-1-phenyl-1H-pyrazole (Compound 1);
- 3-(3-benzyl-3-azabicyclo[3.1.0]hexane-6-carboxamido)methyl-5-isobutyl-1-phenyl-1H-pyrazole (Compound 2);
- 5-isobutyl-1-phenyl-3-{3-[4-(trifluoromethyl)phenylethyl]-3-azabicyclo[3.1.0]hexane-6-carboxamido}methyl-1H-pyrazole (Compound 3);
- 3-(3-benzoyl-3-azabicyclo[3.1.0]hexane-6-carboxamido)methyl-5-isobutyl-1-phenyl-1H-pyrazole (Compound 4);
- 5-isobutyl-1-phenyl-3-[3-(2-phenylacetyl)-3-azabicyclo[3.1.0]hexane-6-carboxamido]methyl-1H-pyrazole (Compound 5);
- 5-isobutyl-1-phenyl-3-(3-benzenesulfonyl-3-azabicyclo[3.1.0]hexane-6-carboxamido)methyl-1H-pyrazole (Compound 6);
- 3-{2-[3-(3,3-dimethylbutyl)-3-azabicyclo[3.1.0]hexane-6-yl]methyl}carbamoyl-5-isobutyl-1-phenyl-1H-pyrazole (Compound 7);
- or
- a pharmaceutically acceptable salt thereof.
Pyrazole-azabicyclo[3.1.0]hexane compounds represented by Formula 2 or salt thereof:
- wherein
- —X—NH—Y— represents —C(O)NH(CH2)q- or —(CH2)qNHC(O)—;
- R1 represents C1-C6 alkyl;
- and
- q represents an integer from 0 to 6.
Dependencies are inferred from the claim text.