US 8,895,600 B2Granted

Non peptidic 14-3-3 inhibitors and the use thereof

AssigneeUniversità Degli Studi Di Siena

InventorsMaurizio Botta, Valentina Corradi, Federico Falchi, Manuela Mancini, Maria Alessandra Santucci

Life of this patent

Estimating the term…

Abstract

The present invention refers to compounds with inhibitory activity against 14-3-3 proteins and their use in the treatment of tumors, in particular chronic myeloid leukemia. The invention also provides methods for the identification of 14-3-3 protein inhibitors.

Claims3

Dependent claims

A method for treating chronic myeloid leukemia or Imatinib-resistant chronic myeloid leukemia comprising administering to a mammal in need thereof an effective amount of compound BV-02

Dependencies are inferred from the claim text.

Facts

Application: 13/571,065Filed 9 Aug 2012 · continuation in part
Priority: 16 Feb 2010
Published: US 2013/0203831 A18 Aug 2013
Granted: 25 Nov 2014
Term ends: Not estimatedThe source records don’t support an estimate.

Classification11 codes

A61K 31/4152
1,2-Diazoles: having oxo groups directly attached to the heterocyclic ring, e.g. antipyrine, phenylbutazone, sulfinpyrazone
A61K 31/196
Having an amino group: the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
A61K 31/4035
Condensed with carbocyclic rings, e.g. carbazole: isoindoles, e.g. phthalimide
A61P 35/02
Antineoplastic agents: specific for leukemia

Family

Application61/304,977Us provisional application · filed 16 Feb 2010
PCT/IB2011/050640Parent of this continuation-in-part · filed 16 Feb 2011
US 2013/0203831 A1Pre-grant publication · published 8 Aug 2013
US 8,895,600 B2This patent

From the US filing history. Foreign family members aren’t listed.

Timeline

Citations

Open elsewhere

patentgrep

Loading patent…

patentgrepSearch patents

Back to results