Lipoprotein lipase-activating compositions comprising benzene derivates

A method for activating LPL in a patient in need of LPL activation treatment, comprising administering an effective amount of a benzene compound into the patient, the benzene compound being represented by General Formula (1):

• wherein R1 is lower alkoxy;
• R2, R3 and Z are any one of the groups (1-1) to (1-3):
• (1-1) R2 is phenyl, phenyl having one or two halogen atoms as substituents on the benzene ring, phenyl lower alkyl group, phenyl lower alkyl group having on the benzene ring one or two substituents selected from the group consisting of halogen, and cyano, or R1 and R2 are jointed to form —CH═C(Ph)- (wherein Ph is phenyl);
• R3 is hydrogen or lower alkoxy;
• and Z is a group represented by the formula below:
• wherein R4 is hydrogen, lower alkyl, or halogen;
• R5 is hydrogen, lower alkyl, halogen, hydroxy, lower alkoxy, phenyl lower alkoxy;
• R6 is hydrogen, lower alkyl, carboxy, or halogenated lower alkyl;
• R7 is hydrogen, lower alkyl, halogen, halogenated lower alkyl, lower alkoxycarbonyl, carboxy, cyano, carbamoyl, or phenyl;
• and
• R8 is hydrogen or lower alkyl;
• (1-2) R2 is phenyl lower alkyl having one or two halogen atoms as substituents on the benzene ring:
• R3 is hydrogen or lower alkoxy;
• and Z is imidazo[2,1-b]thiazol-6-yl or imidazo[2,1-b]thiazol-6-yl having one lower alkyl substituent;
• and
• (1-3) R2 is phenyl lower alkyl, or phenyl lower alkyl having one or two halogen atoms as substituents on the benzene ring;
• R3 is hydrogen or lower alkoxy;
• and Z is imidazo[1,2-a]pyridin-3-yl.