Back to results
US 8,895,582 B2Granted
Certain chemical entities, compositions, and methods
AssigneeCytokinetics, Inc.
InventorsXiangping Qian, Chihyuan (Grace) Chuang, Pu-Ping Lu, Bing Yao, Qing (Kevin) Lu, Hong Jiang, Wenyue Wang, Bradley P. Morgan, David J. Morgans, Jr.
Life of this patent
Estimating the term…
Abstract
Chemical entities that modulate smooth muscle myosin and/or non-muscle myosin, pharmaceutical compositions and methods of treatment of diseases and conditions associated with smooth muscle myosin and/or non-muscle myosin are described.
Claims45
A compound of Formula I
- or a pharmaceutically acceptable salt thereof, wherein
- W1 is O;
- W2 is NR13;
- W3 is NR14;
- Z1 is selected from isoquinolinyl, thiadiazolyl, and isoxazolyl;
- Z2 is phenyl;
- R8 is selected from hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted aryl, optionally substituted heteroaryl, and optionally substituted heterocycloalkyl;
- R13 and R14 are independently selected from hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted cycloalkyl, and optionally substituted heterocycloalkyl;
- for each occurrence, R3, R4, and R5 are independently selected from hydrogen, hydroxy, carboxy, sulfonyl, sulfinyl, sulfanyl, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted alkoxy, optionally substituted aryloxy, optionally substituted heteroaryloxy, optionally substituted heterocycloalkyloxy, optionally substituted aminocarbonyloxy, optionally substituted acyloxy, optionally substituted alkoxycarbonyloxy, optionally substituted acyl, optionally substituted alkoxycarbonyl, optionally substituted amino, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aminocarbonyl, and optionally substituted aminosulfonyl;
- R7 and R10 are independently selected from hydrogen, cyano, halo, hydroxy, azido, nitro, carboxy, sulfinyl, sulfanyl, optionally substituted alkoxy, optionally substituted aryloxy, optionally substituted heteroaryloxy, optionally substituted heterocycloalkyloxy, optionally substituted alkoxycarbonyl, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted aryloxy, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocycloalkyl, optionally substituted amino, optionally substituted acyl, optionally substituted alkoxycarbonyl, optionally substituted aminocarbonyl, optionally substituted aminosulfonyl, optionally substituted carbaminodoyl, and optionally substituted alkynyl;
- m is selected from 0, 1, 2, and 3;
- n is selected from 0, 1, 2, 3, and 4;
- —(CR5R6)q— is —CH2CH(R5)—;
- and
- p is selected from 0, 1, 2, and 3.
12 more elements
A compound of Formula I
- or a pharmaceutically acceptable salt thereof, wherein
- W1 is O;
- W2 is NR13;
- W3 is NR14;
- Z1 is selected from isoquinolinyl, thiadiazolyl, and isoxazolyl;
- Z2 is phenyl;
- R3 is hydrogen;
- R4 is hydrogen;
- —(CR5R8)g— is —CH2CH(R5)—;
- R5 is lower alkyl substituted with one, two, or three groups selected from hydroxy and phosphato;
- R7 and R10 are independently selected from hydrogen, cyano, halo, hydroxy, azido, nitro, carboxy, sulfinyl, sulfanyl, optionally substituted alkoxy, optionally substituted aryloxy, optionally substituted heteroaryloxy, optionally substituted heterocycloalkyloxy, optionally substituted alkoxycarbonyl, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted aryloxy, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocycloalkyl, optionally substituted amino, optionally substituted acyl, optionally substituted alkoxycarbonyl, optionally substituted aminocarbonyl, optionally substituted aminosulfonyl, optionally substituted carbaminodoyl, and optionally substituted alkynyl;
- R8 is selected from hydrogen and alkyl;
- R13 and R14 are independently selected from hydrogen and alkyl;
- m is selected from 0, 1, 2, and 3;
- n is 1;
- and
- p is selected from 0, 1, 2, and 3.
14 more elements
Dependencies are inferred from the claim text.