1 H-pyrrolo[2,3-b]pyridine derivatives

A method for the treatment of a tumour, tumour growth, or tumour metastases where the tumour, tumour growth, or tumour metastases originates from acute myeloid leukaemia, chronic myeloid leukaemia, acute lymphatic leukaemia or chronic lymphatic leukaemia, comprising administering to a subject in need thereof an effective amount of one of the following compounds

• No.
• Structure/name
• “A1”
• N4-(3-Fluorophenyl)-N4-methyl-6-[5-(1-methyl-1H-pyrazol-4-yl)-
• 1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidine-2,4-diamine
• “A2”
• 4-(1-Methyl-1-phenylethyl)-6-[5-(1-methyl-1H-pyrazol-4-yl)-1H-
• pyrrolo[2,3-b]pyridin-3-yl]pyrimidin-2-ylamine
• “A3”
• 4-[5-(1-Methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-
• 6-(1-phenylcyclopropyl)pyrimidin-2-ylamine
• “A4”
• 2-({2-Amino-6-[5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]-
• pyridin-3-yl]pyrimidin-4-yl}phenylamino)ethanol
• “A5”
• (S)-3-[{2-Amino-6-[5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-
• b]-pyridin-3-yl]pyrimidin-4-yl}-(4-methoxyphenyl)amino]
• propane-1,2-diol
• “A6”
• 4-[5-(1-Methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-
• 6-(1-phenylcyclopentyl)pyrimidin-2-ylamine
• “A7”
• 4-[1-(4-Chlorophenyl)cyclopentyl]-6-[5-(1-methyl-1H-pyrazol-4-
• yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidin-2-ylamine
• “A8”
• N4-(3-Chlorophenyl)-N4-methyl-6-[5-(1-methyl-1H-pyrazol-4-yl)-
• 1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidine-2,4-diamine
• “A9”
• N4-(2-Fluorophenyl)-N4-methyl-6-[5-(1-methyl-1H-pyrazol-4-yl)-
• 1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidine-2,4-diamine
• “A10”
• N4-(2-Chlorophenyl)-N4-methyl-6-[5-(1-methyl-1H-pyrazol-4-yl)-
• 1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidine-2,4-diamine
• “A11”
• N4-Methyl-6-[5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]-
• pyridin-3-yl]-N4-phenylpyrimidine-2,4-diamine
• “A12”
• N4-Ethyl-6-[5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-
• b]pyridin-3-yl]-N4-phenylpyrimidine-2,4-diamine
• “A13”
• N4-(4-Chlorophenyl)-N4-ethyl-6-[5-(1-methyl-1H-pyrazol-4-yl)-
• 1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidine-2,4-diamine
• “A14”
• N4-Benzyl-N4-ethyl-6-[5-(1-methyl-1H-pyrazol-4-yl)-1H-
• pyrrolo[2,3-b]pyridin-3-yl]pyrimidine-2,4-diamine
• “A15”
• 2-[{2-Amino-6-[5-(1-isopropyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-
• b]-pyridin-3-yl]pyrimidin-4-yl}-(2-chlorophenyl)amino]ethanol
• “A16”
• 2-[{2-Amino-6-[5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]-
• pyridin-3-yl]pyrimidin-4-yl}-(2-chlorophenyl)amino]ethanol
• “A17”
• 4-(5-Fluoro-2,3-dihydroindol-1-yl)-6-[5-(1-methyl-1H-pyrazol-4-
• yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidin-2-ylamine
• “A18”
• 4-(5-Fluoro-2,3-dihydroindol-1-yl)-6-[5-(1-isopropyl-1H-pyrazol-
• 4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidin-2-ylamine
• “A19”
• N4-(2-Chlorophenyl)-6-[5-(1-isopropyl-1H-pyrazol-4-yl)-1H-
• pyrrolo[2,3-b]pyridin-3-yl]-N4-methylpyrimidine-2,4-diamine
• “A20”
• N4-Ethyl-6-[5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-
• b]pyridin-3-yl]-N4-1,3,4-thiadiazol-2-ylpyrimidine-2,4-diamine
• “A21”
• 1-({2-Amino-6-[5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]-
• pyridin-3-yl]pyrimidin-4-yl}phenylamino)-3-methoxypropan-2-ol
• “A22”
• 3-[{2-Amino-6-[5-(1-methyl-1H-pyrazol-4-yl)-1H-
• pyrrolo[2,3-b]-pyridin-3-yl]pyrimidin-4-yl}-(2,3-
• dihydroxypropyl)amino]benzonitrile
• “A23”
• 3-[{2-Amino-6-[5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]-
• pyridin-3-yl]pyrimidin-4-yl}-(2-chlorophenyl)amino]propionic
• acid
• “A24”
• Methyl [{2-amino-6-[5-(1-methyl-1H-pyrazol-4-yl)-1H-
• pyrrolo[2,3-b]pyridin-3-yl]pyrimidin-4-yl}-(4-
• chlorophenyl)amino]-acetate
• “A25”
• 2-[{2-Amino-6-[5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]-
• pyridin-3-yl]pyrimidin-4-yl}-(2,4-difluorophenyl)amino]ethanol
• “A26”
• 2-[{2-Amino-6-[5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]-
• pyridin-3-yl]pyrimidin-4-yl}-(2-fluorophenyl)amino]ethanol
• “A27”
• 4-(2,3-Dihydrobenzo-1,4-oxazin-4-yl)-6-[5-(1-methyl-1H-pyrazol-
• 4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidin-2-ylamine
• “A28”
• N4-(3-Fluorophenyl)-6-[5-(1-methyl-1H-pyrazol-4-yl)-1H-
• pyrrolo[2,3-b]pyridin-3-yl]-N4-(2-morpholin-4-
• ylethyl)pyrimidine-2,4-diamine
• “A29”
• N4-(2-Chlorophenyl)-N4-(2-methoxyethyl)-6-[5-(1-methyl-1H-
• pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidine-2,4-
• diamine
• “A30”
• 3-({2-Amino-6-[5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]-
• pyridin-3-yl[pyrimidin-4-yl}phenylamino)propionitrile
• “A30a”
• (3-Fluorophenyl)methyl-{6-[5-(1-methyl-1H-pyrazol-4-yl)-1H-
• pyrrolo[2,3-b]pyridin-3-yl[pyrimidin-4-yl}amine
• “A31”
• N4-(3-Aminopropyl)-6-[5-(1-methyl-1H-pyrazol-4-yl)-1H-
• pyrrolo[2,3-b]pyridin-3-yl]-N4-phenylpyrimidine-2,4-diamine
• “A32”
• N4-(3-Aminopropyl)-6-[5-(1-methyl-1H-pyrazol-4-yl)-1H-
• pyrrolo[2,3-b]pyridin-3-yl]-N4-(2-methylpyridin-4-yl)pyrimidine-
• 2,4-diamine
• “A33”
• 3-[{2-Amino-6-[5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]-
• pyridin-3-yl]pyrimidin-4-yl}-(2-methylpyridin-4-yl)amino]-
• propionitrile
• “A34”
• 4-[5-(1-Methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-
• 6-[1-(2-methylpyridin-4-yl)cyclopropyl]pyrimidin-2-ylamine
• “A35”
• 3-({2-Amino-6-[5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]-
• pyridin-3-yl]pyrimidin-4-yl}phenylamino)propionamide
• “A36”
• 3-[{2-Amino-6-[5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]-
• pyridin-3-yl]pyrimidin-4-yl}-(2-methylpyridin-4-yl)amino]-
• propionamide
• “A37”
• N4-(2-Methoxyethyl)-6-[5-(1-methyl-1H-pyrazol-4-yl)-1H-
• pyrrolo[2,3-b]pyridin-3-yl]-N4-(2-methylpyridin-4-yl)pyrimidine-
• 2,4-diamine
• “A38”
• N4-(2-Methoxyethyl)-6-[5-(1-methyl-1H-pyrazol-4-yl)-1H-
• pyrrolo[2,3-b]pyridin-3-yl]-N4-(1-methylpyrazol-4-yl)pyrimidine-
• 2,4-diamine
• “A39”
• N4-(3-Aminopropyl)-6-[5-(1-methyl-1H-pyrazol-4-yl)-1H-
• pyrrolo[2,3-b]pyridin-3-yl]-N4-(2-chlorophenyl)pyrimidine-2,4-
• diamine
• “A40”
• 3-[{2-Amino-6-[5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]-
• pyridin-3-yl]pyrimidin-4-yl}-(2-chlorophenyl)amino]propionamide
• “A41”
• 3-[{2-Amino-6-[5-(1-isopropyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-
• b]-pyridin-3-yl]pyrimidin-4-yl}-(2-methylpyridin-4-yl)amino]-
• propionamide
• “A42”
• 4-[1-(2-Fluorophenyl)cyclopropyl]-6-[5-(1-methyl-1H-pyrazol-4-
• yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidin-2-ylamine
• “A43”
• N-[3-({2-Amino-6-[5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-
• b]-pyridin-3-yl]pyrimidin-4-yl}phenylamino)propyl]acetamide
• or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof.