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US 8,895,565 B2Granted
Heterocyclic compound and use of the same
OwnerTetsuya Nishioinventor
Life of this patent
Estimating the term…
Abstract
Provided is a compound represented by general formula (6) and pharmaceutically acceptable salts thereof. (In the formula, R1 is a hydrogen atom or a C1-6 alkyl group; R2 is a hydrogen atom or a C1-6 alkyl group; R3 is a hydrogen atom, a halogen atom, a C1-6 alkyl group, or a C1-6 haloalkyl group.)
Claims19
A compound represented by general formula (1A):
- wherein q is an integer selected from 0, 1, and 2;
- R1 is a hydrogen atom, a halogen atom, a C1-6 alkyl group, a C1-6 haloalkyl group, a C3-8 cycloalkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-6 alkoxy C1-6 alkyl group, an aralkyl group which may have one or more substituents, an aryl group which may have one or more substituents, an amino C1-6 alkyl group which may have one or more substituents, a heterocyclic group which may have one or more substituents, or a heterocyclic C1-6 alkyl group which may have one or more substituents;
- R2 is a hydrogen atom, a halogen atom, a C1-6 alkyl group, a C1-6 haloalkyl group, a C2-8 cycloalkyl group, a C1-6 alkoxy C1-6 alkyl group, a C1-6 alkoxy group, an aryl group which may have one or more substituents, an aryl C2-6 alkynyl group which may have one or more substituents, a C2-6 alkenyl group which may have one or more substituents, or an aryl C2-6 alkenyl group which may have one or more substituents;
- R3 is a nitro group, a cyano group, a carbamoyl group, a C1-6 haloalkyl group, a C1-6 alkoxy group, a C1-6 alkoxy C1-6 alkyl group, a C2-6 alkynyl group which may have one or more substituents, an aryl C2-6 alkynyl group which may have one or more substituents, a C2-6 alkenyl group which may have one or more substituents, an aryl C2-6 alkenyl group which may have one or more substituents, a C3-6 cycloalkenyl group, a C4-6 cycloalkadienyl group, or a heterocyclic group which may have one or more substituents;
- R4 is a hydrogen atom, a C1-6 alkyl group, or a C3-8 cycloalkyl group;
- R5 is a hydrogen atom, a C1-6 alkyl group, a C3-8 cycloalkyl group, a C1-6 alkoxy group, a C1-6 alkylsulfanyl group, a C1-6 alkylsulfinyl group, a C1-6 alkylsulfonyl group, an amino group which may have one or more substituents, a C1-6 haloalkyl group, a halogen atom, an aralkyl group which may have one or more substituents, a C2-6 alkynyl group which may have one or more substituents, an aryl C2-6 alkynyl group which may have one or more substituents, a C2-6 alkenyl group which may have one or more substituents, an aryl C2-6 alkenyl group which may have one or more substituents, a heterocyclic group which may have one or more substituents, or an aryl group which may have one or more substituents;
- R6 is independently a C1-6 alkoxy group, a halogen atom, a nitro group, a C2-6 alkynyl group which may have one or more substituents, or a C1-6 alkyl group;
- G and J are each independently a nitrogen atom;
- W is a single bond, C(O), S(O), S(O)2 or an oxygen atom;
- X is a C1-6 alkylene group;
- Y is an oxygen atom, or a sulfur atom;
- and Z is a single bond, an oxygen atom, O(CH2)O, O(CH2CH2)O, O(CH2CH2CH2)O, O(CH2)C(O), O(CH2CH2)C(O), O(CH2CH2CH2)C(O), NH, N(CH2), or N(C2H5), or
- a pharmaceutically acceptable salt thereof.
10 more elements
A compound represented by general formula (2):
- wherein R1 is a hydrogen atom, a halogen atom, a C1-6 alkyl group, a C3-8 cycloalkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, an aralkyl group which may have one or more substituents, a C1-6 alkoxy C1-6 alkyl group, an aryl group which may have one or more substituents, an amino C1-6 alkyl group which may have one or more substituents, a heterocyclic group which may have one or more substituents, or a heterocyclic C1-6 alkyl group which may have one or more substituents;
- R2 is a hydrogen atom, a halogen atom, a C1-6 alkyl group, a C1-6 haloalkyl group, a C3-8 cycloalkyl group, a C1-6 alkoxy C1-6 alkyl group, a C1-6 alkoxy group, an aryl group which may have one or more substituents, a C2-6 alkynyl group which may have one or more substituents, an aryl C2-6 alkynyl group which may have one or more substituents, a C2-6 alkenyl group which may have one or more substituents, or an aryl C2-6 alkenyl group which may have one or more substituents;
- R3 is a hydrogen atom, a halogen atom, a nitro group, a cyano group, a carbamoyl group, a carboxyl group, a C1-6 alkyl group, a C1-6 haloalkyl group, a C1-6 alkoxy group, a C1-6 alkoxy C1-6 alkyl group, a C1-6 alkoxycarbonyl group, a C2-6 alkynyl group which may have one or more substituents, an aryl C2-6 alkynyl group which may have one or more substituents, a C2-6 alkenyl group which may have one or more substituents, an aryl C2-6 alkenyl group which may have one or more substituents, a heterocyclic group which may have one or more substituents, or an aryl group which may have one or more substituents;
- R4 is a hydrogen atom, a C1-6 alkyl group, or a C3-8 cycloalkyl group;
- R5 is a hydrogen atom, a C1-6 alkyl group, a C3-8 cycloalkyl group, a C1-6 alkoxy group, a C1-6 alkylsulfanyl group, a C1-6 alkylsulfinyl group, a C1-6 alkylsulfonyl group, an amino group which may have one or more substituents, a C1-6 haloalkyl group, a halogen atom, an aralkyl group which may have one or more substituents, a C2-6 alkynyl group which may have one or more substituents, an aryl C2-6 alkynyl group which may have one or more substituents, a C2-6 alkenyl group which may have one or more substituents, an aryl C2-6 alkenyl group which may have one or more substituents, a heterocyclic group which may have one or more substituents, or an aryl group which may have one or more substituents;
- G is a nitrogen atom;
- J is a nitrogen atom;
- X is a C1-6 alkylene group;
- Y is an oxygen atom, or a sulfur atom;
- and Z is a single bond, an oxygen atom, O(CH2)O, O(CH2CH2)O, O(CH2CH2CH2)O, O(CH2)C(O), O(CH2CH2)C(O), O(CH2CH2CH2)C(O), NH, N(CH3), or N(C2H5), or
- a pharmaceutically acceptable salt thereof.
8 more elements
A compound represented by general formula (3):
- wherein R1 is a hydrogen atom, a C1-6 alkyl group, a C3-8 cycloalkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, or an aralkyl group which may have one or more substituents;
- R2 is a hydrogen atom, a halogen atom, a C1-6 alkyl group, a C1-6 haloalkyl group, a C1-6 alkoxy C1-6 alkyl group, a C1-6 alkoxy group, an aryl group which may have one or more substituents, a C2-6 alkynyl group which may have one or more substituents, an aryl C2-6 alkynyl group which may have one or more substituents, a C2-6 alkenyl group which may have one or more substituents, or an aryl C2-6 alkenyl group which may have one or more substituents;
- and R3 is a hydrogen atom, a halogen atom, a cyano group, a carbamoyl group, a carboxyl group, a C1-6 alkyl group, a C1-6 haloalkyl group, a C1-6 alkoxy group, a C1-6 alkoxycarbonyl group, a C2-6 alkynyl group which may have one or more substituents, an aryl C2-6 alkynyl group which may have one or more substituents, an aryl C2-6 alkenyl group which may have one or more substituents, a C2-6 alkenyl group which may have one or more substituents, or an aryl group which may have one or more substituents, or
- a pharmaceutically acceptable salt thereof.
1 more element
A compound represented by general formula (4):
- wherein p is an integer selected from 0, 1, 2 and 3;
- R1 is a hydrogen atom, a C1-6 alkyl group, a C3-8 cycloalkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, an aralkyl group which may have one or more substituents, an amino C1-6 alkyl group which may have one or more substituents, a heterocyclic group which may have one or more substituents, or a heterocyclic C1-6 alkyl group which may have one or more substituents;
- R2 is a hydrogen atom, a C1-6 alkyl group, a C1-6 haloalkyl group, or a halogen atom;
- R3 is independently a halogen atom, a C1-6 haloalkyl group, a C1-6 alkyl group, a C1-6 alkoxy group, or a C1-6 haloalkoxy group;
- R4 is a hydrogen atom or a C1-6 alkyl group;
- R5 is a hydrogen atom, a C1-6 alkyl group, a C3-8 cycloalkyl group, a C1-6 haloalkyl group, or a halogen atom;
- X is a C1-6 alkylene group;
- Y is an oxygen atom or a sulfur atom;
- and Z is a single bond, an oxygen atom, O(CH2)O, O(CH2CH2)O, O(CH2)C(O), O(CH2CH2)C(O), NH, N(CH3), or N(C2H5), or
- a pharmaceutically acceptable salt thereof.
7 more elements
A compound represented by general formula (5):
- wherein p is an integer selected from 0, 1, 2 and 3, R1 is a hydrogen atom or a C1-6 alkyl group;
- R2 is a hydrogen atom, a halogen atom, a C1-6 alkyl group, or a C1-6 haloalkyl group;
- and R3 is independently a halogen atom, a C1-6 alkyl group, or a C1-6 haloalkyl group, or
- a pharmaceutically acceptable salt thereof.
1 more element
A compound represented by general formula (6):
- wherein R1 is a hydrogen atom or a C1-6 alkyl group;
- R2 is a hydrogen atom or a C1-6 alkyl group;
- and R3 is a hydrogen atom, a halogen atom, a C1-6 alkyl group, or a C1-6 haloalkyl group, or
- a pharmaceutically acceptable salt thereof.
1 more element
A compound represented by general formula (7):
- wherein R1 is a methyl group or an ethyl group;
- and R2 is a methyl group or an ethyl group, or
- a pharmaceutically acceptable salt thereof.
A compound selected from the group consisting of:
- methyl 5-(6-methyl-5-{[4-(trifluoromethyl)phenyl]ethynyl}pyrimidin-4-ylaminomethyl)-2-furancarboxylate;
- and
- ethyl 5-(6-methyl-5-{[4-(trifluoromethyl)phenyl]ethynyl}pyrimidin-4-ylaminomethyl)-2-furancarboxylate, or
- a pharmaceutically acceptable salt thereof.
1 more element
A compound selected from the group consisting of:
- methyl 5-(5-{[4-(trifluoromethyl)phenyl]ethynyl}pyrimidin-4-ylaminomethyl)-2-furancarboxylate;
- and
- ethyl 5-(5-{[4-(trifluoromethyl)phenyl]ethynyl}pyrimidin-4-ylaminomethyl)-2-furancarboxylate, or
- a pharmaceutically acceptable salt thereof.
1 more element
A compound selected from the group consisting of:
- methyl 5-(2-isopropyl-6-methyl-5-{[4-(trifluoromethyl)phenyl]ethynyl}pyrimidin-4-ylaminomethyl)-2-furancarboxylate;
- ethyl 5-(2-isopropyl-6-methyl-5-{[4-(trifluoromethyl)phenyl]ethynyl}pyrimidin-4-ylaminomethyl)-2-furancarboxylate;
- methyl 5-(2,6-dimethyl-5-{[4-(trifluoromethyl)phenyl]ethynyl}pyrimidin-4-ylaminomethyl)-2-furancarboxylate;
- and
- ethyl 5-(2,6-dimethyl-5-{[4-(trifluoromethyl)phenyl]ethynyl}pyrimidin-4-ylaminomethyl)-2-furancarboxylate, or
- a pharmaceutically acceptable salt thereof.
3 more elements
Dependencies are inferred from the claim text.