Compounds, compositions and methods for the treatment of amyloid diseases and synucleinopathies such as Alzheimer's disease, type 2 diabetes, and Parkinson's disease
AssigneeProteotech, Inc.
InventorsAlan D. Snow, Beth Nguyen, Gerardo Castillo, Virginia Sanders, Thomas Lake
Life of this patent
Estimating the term…
Abstract
Bis- and tris-dihydroxyaryl compounds and their methylenedioxy analogs and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of amyloid diseases, especially Aβ amyloidosis, such as observed in Alzheimer's disease, IAPP amyloidosis, such as observed in type 2 diabetes, and synucleinopathies, such as observed in Parkinson's disease, and the manufacture of medicaments for such treatment.
Claims19
A method of treating the formation, deposition, accumulation, or persistence of amyloid and synuclein fibrils, comprising treating the fibrils with an effective amount of a compound of the formula A-R-B or a pharmaceutically acceptable salt thereof;
- where, R is a 6 membered heterocyclic ring which can optionally comprise up to two heteroatoms which are nitrogen, the heterocyclic ring is saturated or unsaturated and where any of the ring members can be optionally substituted with one or more groups selected from hydrogen and methyl;
- and where, A and B are unsubstituted dihydroxybenzyls wherein the benzyl methylene group is independently saturated or unsaturated and can be optionally substituted with a group selected from a hydrogen or ether.
A method of treating and/or relieving a synucleinopathy in a mammal suffering therefrom, comprising administration to the mammal of a therapeutically effective amount of a compound of the formula A-R-B or a pharmaceutically acceptable salt thereof;
- where, R is a 6 membered heterocyclic ring which can optionally comprise up to two heteroatoms which are nitrogen, the heterocyclic ring is saturated or unsaturated and where any of the ring members can be optionally substituted with one or more groups selected from hydrogen and methyl;
- and
- where, A and B are unsubstituted dihydroxybenzyls wherein the benzyl methylene group is independently saturated or unsaturated and can be optionally substituted with a group selected from a hydrogen or ether.
A method of treating and/or relieving an amyloid disease in a mammal suffering therefrom, comprising administration to the mammal of a therapeutically effective amount of a compound of the formula A-R-B or a pharmaceutically acceptable salt thereof;
- where, R is a 6 membered heterocyclic ring which can optionally comprise up to two heteroatoms which are nitrogen, the heterocyclic ring is saturated or unsaturated and where any of the ring members can be optionally substituted with one or more groups selected from hydrogen and methyl;
- and
- where, A and B are unsubstituted dihydroxybenzyls wherein the benzyl methylene group is independently saturated or unsaturated and can be optionally substituted with a group selected from a hydrogen or ether.
Dependencies are inferred from the claim text.