Cyclic amide derivative
AssigneeSumitomo Dainippon Pharma Co., Ltd.
InventorsYoshihiro Horiuchi, Hiroaki Fujiwara, Hitoshi Suda, Izumi Sasaki, Mitsutaka Iwata, Kiyoto Sawamura
Life of this patent
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Abstract
Provided is a compound represented by formula (1) or a pharmacologically acceptable salt thereof. (In the formula, A is C6-10 arylene, etc.; R1a, R1b and R1c each independently is a hydrogen atom, a halogen atom, a C1-4 alkyl group, a C1-4 alkoxy group, etc.; R2 is an optionally substituted C6-10 aryl group, an optionally substituted 5- to 12-membered monocyclic or polycyclic heteroaryl group, an optionally substituted C7-16 aralkyl group, etc.; m is 0, etc.; n is an integer of 0 to 2.)
Claims32
A compound of formula (1), or a pharmaceutically acceptable salt thereof:
- [wherein A is C6-10 arylene, or 5- or 6-membered monocyclic heteroarylene selected from the group of the following group:
- R1a, R1b and R1c are each independently,
- (1) hydrogen atom,
- (2) deuterium atom,
- (3) halogen atom,
- (4) cyano group,
- (5) C1-4 alkyl group (in which the group may be optionally substituted by
- (a) 1 to 3 halogen atom(s),
- (b) C1-4 alkoxy (in which the group may be optionally substituted by 1 to 3 halogen atom(s)),
- (c) C3-6 cycloalkyl,
- (d) C3-6 cycloalkoxy, or
- (e) heterocycle),
- (6) C1-4 alkoxy group (in which the group may be optionally substituted by
- (a) 1 to 3 halogen atom(s),
- (b) C1-4 alkoxy (in which the group may be optionally substituted by 1 to 3 halogen atom(s)),
- (c) C3-6 cycloalkyl, or
- (d) C3-6 cycloalkoxy),
- (7) C3-6 cycloalkyl group,
- (8) C3-6 cycloalkoxy group,
- (9) heterocyclic oxy group, or
- (10) C7-16 aralkyloxy group;
- R2 is optionally substituted C6-10 aryl group, optionally substituted 5- to 12-membered monocyclic or polycyclic heteroaryl group, optionally substituted C7-16 aralkyl group, optionally substituted 5- to 12-membered monocyclic or polycyclic heteroaryl-C1-6 alkyl group, optionally substituted heterocycle group, or C1-6 alkyl group (in which the alkyl group may be optionally substituted by optionally substituted C6-10 aryloxy);
- m is 0 or 1;
- n is an integer of 0 to 2.]
Dependencies are inferred from the claim text.