Starch derivative mixtures
AssigneeB. Braun Melsungen AG
InventorsBernd Meier, Iris Theresia Jankowiak-Meier, Nele Meier, Clara Meier
Life of this patent
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Abstract
The invention relates to a compound, comprising a) a first starch derivative selected from the group consisting of hydroxyalkyl starch, carboxyl alkyl starch, ester starch and arbitrary mixtures thereof, wherein the starch derivative has a mean relative molar mass Mw1 and a degree of molar substitution MS1, and b) a second starch derivative selected from the group consisting of hydroxyalkyl starch, carboxyl alkyl starch, ester starch and arbitrary mixtures thereof, having a mean relative molar mass Mw2 and a degree of molar substitution MS2, characterized in that Mw1 is greater than Mw2 (Mw1>Mw2) and MS2 is greater than MS1 (MS2>MS1).
Claims17
A pharmaceutical formulation comprising
- a) a composition comprising
- i) a first starch derivative selected from the group consisting of hydroxyalkyl starch, carboxyalkyl starch, ester starch and any mixtures thereof, the first starch derivative having an average molecular weight Mw1 and a molar substitution MS1;
- and
- ii) a second starch derivative selected from the group consisting of hydroxyalkyl starch, carboxyalkyl starch, ester starch and any mixtures thereof, with an average molecular weight Mw2 and a molar substitution MS2;
- wherein Mw1 is greater than Mw2 (Mw1>Mw2), and MS2 is greater than MS1 (MS2>MS1), wherein the weight ratio of the first starch derivative to the second starch derivative is from 1:9 to 9:1, and wherein the second starch derivative has an average molecular weight Mw2 from 30,000 to 80,000 daltons;
- and
- b) one or more electrolytes selected from the group consisting of sodium chloride, potassium chloride, magnesium acetate and magnesium chloride.
A process for the preparation of a pharmaceutical formulation, comprising the following steps:
- a) providing a first starch derivative selected from the group consisting of hydroxyalkyl starch, carboxyalkyl starch, ester starch and any mixtures thereof, the first starch derivative having an average molecular weight Mw1 and a molar substitution MS1;
- b) providing a second starch derivative selected from the group consisting of hydroxyalkyl starch, carboxyalkyl starch, ester starch and any mixtures thereof, with an average molecular weight Mw2 and a molar substitution MS2, wherein Mw1 is greater than Mw2 (Mw1>Mw2), and MS2 is greater than MS1 (MS2>MS1);
- c) providing one or more electrolytes selected from the group consisting of sodium chloride, potassium chloride, magnesium acetate and magnesium chloride;
- and
- d) mixing said first starch derivative with said second starch derivative and said one or more electrolytes, wherein the first starch derivative and the second starch derivative are present in the pharmaceutical formulation in a weight ratio of from 1:9 to 9:1 and wherein the second starch derivative has an average molecular weight Mw2 from 30,000 to 80,000 daltons.
Dependencies are inferred from the claim text.