Back to results
US 8,895,521 B2Granted
Methods and compositions for the treatment of uveitis
AssigneeThe United States of America, as represented by the Secretary, Department of Health and Human Services
InventorsDennis M. Klinman, Igal Gery, Chiaki Fujimoto
Life of this patent
Estimating the term…
Abstract
Pharmaceutical compositions are disclosed that are of use for the treatment of uveitis. These compositions include a suppressive oligonucleotide. These compositions including an immunosuppressive oligonucleotide can be used for the treatment of uveitis, including anterior, posterior, and diffuse uveitis.
Claims17
A method of reducing uveitis in a subject, comprising
- selecting an isolated oligodeoxynucleotide consisting of the nucleic acid sequence set forth as SEQ ID NO:
- 2;
- and
- systemically or intraocularly administering to the subject in need thereof a therapeutically effective amount of a composition comprising the selected isolated oligodeoxynucleotide and a pharmaceutically acceptable carrier to suppress production of interleukin (IL-4) and interferon gamma, and thereby reducing ocular inflammation in the subject.
1 more element
Dependencies are inferred from the claim text.