Method for treating a human patent suffering from Myeloid Neoplasias using 5-aminoimidazole-4-carboxamide

A method for treating a human patient suffering from myeloid neoplasias, comprising administrating a therapeutically effective amount of a compound of formula (I):

• salt thereof, together with appropriate amounts of pharmaceutically acceptable diluents or carriers;
• wherein, R2, R3and R5are radicals independently selected from the group consisting of —H, —PO(OH)2, —PO(OH)—O—PO(OH)2, —PO(OH)—O—PO(OH)—O—PO(OH)2, —CO—R′ and —CO—OR′;
• R′ being a hydrocarbyl radical up to twelve carbon atoms, which may be an aliphatic substituent selected from alkyl, alkenyl, and alkynyl groups and groups which have a mixture of saturated and unsaturated bonds, alicyclic, aryl, and a combination thereof;
• wherein R′ may be a radical selected from a straight-chain, a branched-chain, a cyclic moiety, and a combination thereof;
• R′ may have one or more hydrogen atoms substituted for by one or more halogen atoms, and/or by one or more (C1-C4)-alkyl groups;
• R′ may have one or more CH2groups substituted for by one or more NH, O and/or S groups;
• and R′ may have one or more CH groups substituted by one or more N atoms.