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AssigneeGeorgia Tech Research Corporation
InventorsJohn McDonald, Nathan John Bowen, LiJuan Wang
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The present invention provides a method of treating an ovarian cancer, the method comprising delivering one or more miR-200 family members to a mammalian subject in need thereof in an amount effective to treat the ovarian cancer. Also provided are methods of preventing metastasis of an ovarian cancer, the method comprising delivering one or more miR-200 family members to a mammalian subject in need thereof in an amount effective to prevent metastasis. Further provided are methods of sensitizing an ovarian cancer to a cytotoxic therapy, the method comprising delivering one or more miR-200 family members to a mammalian subject in need thereof in an amount effective to sensitize the ovarian cancer to the cytotoxic therapy. The invention also contemplates methods of reducing epithelial-to-mesenchymal transition (EMT) in an ovarian cancer or cancer cell as well as methods of inducing mesenchymal-to-epithelial transition (MET).
A method of sensitizing an ovarian cancer to a cytotoxic therapy, the method comprising delivering a modified miR-429, wherein the modified miR-429 comprises a seed sequence, AAUACUG, and further wherein the modified miR-429 comprises one or more nucleotide substitutions and/or deletions in the nucleotide sequence of SEQ ID NO:5 outside of the seed sequence, to a mammalian subject in need thereof in an amount effective to sensitize the ovarian cancer to cytotoxic therapy.
Dependencies are inferred from the claim text.