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US 8,895,507 B2Granted
Modulation of synaptogenesis
AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorsBen A. Barres, Cagla Eroglu
Life of this patent
Estimating the term…
Abstract
Soluble proteins, e.g. Hevin, can trigger synapse formation; and other soluble proteins, e.g. SPARC antagonize this activity. Such proteins are synthesized in vitro and in vivo by astrocytes. Methods are provided for protecting or treating an individual suffering from adverse effects of deficits in synaptogenesis, or from undesirably active synaptogenesis.
Claims4
A method of enhancing synaptogenesis in an individual with glaucoma comprising the step of:
- contacting a retinal ganglion cell in an individual with glaucoma with an effective dose of a SEQ ID NO:1 polypeptide;
- wherein the number of synapses is increased in said retinal ganglion cell relative to a retinal ganglion cell that is not contacted with a SEQ ID NO:1 polypeptide.
Dependencies are inferred from the claim text.