Method of treatment of type 2 diabetes
AssigneeAdiStem Ltd.
InventorsVasilis Paspaliaris, James Thornton
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Abstract
Provided is a method of treating type 2 diabetes in a subject, comprising administering a polypeptide comprising thymosin, or an active fragment or variant thereof, preferably comprising or consisting of the peptide LKKTETQ (SEQ ID NO: 1).
Claims10
A method of improving glycemic control in a subject having type 2 diabetes, comprising administering to the subject an effective amount of a peptide of an amino acid sequence selected from the group consisting of LKKTETQ (SEQ ID NO:1), FDKSKLKKTETQEKN (SEQ ID NO:4), FDKAKLKKTETQEKN (SEQ ID NO:5), FDKTKLKKTETQEKN (SEQ ID NO:7), and FNRAKLKKTETQEKN (SEQ ID NO:11), to improve glycemic control, wherein the peptide comprises at least one modification selected from the group consisting of at least one D-amino acid residue, an N-terminal acyl modification, a C-terminal hydroxyl modification, and both an N-terminal acyl modification and a C-terminal hydroxyl modification.
A method of improving glycemic control in a subject having type 2 diabetes, comprising administering to the subject an effective amount of a peptide consisting of LKKTETQ (SEQ ID NO:1) to improve glycemic control, wherein the peptide comprises at least one modification selected from the group consisting of at least one D-amino acid residue, an N-terminal acyl modification, a C-terminal hydroxyl modification, and both an N-terminal acyl modification and a C-terminal hydroxyl modification.
Dependencies are inferred from the claim text.