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AssigneeToray Industries, Inc.
InventorsMariko Morishita, Kozo Takayama, Reiji Nishio, Nobuo Ida
Estimating the term…
A method for nasal administration of a pharmaceutical composition comprising a hydrophilic bioactive substance and any one of (a) to (c): (a) a peptide having the amino acid sequence shown in SEQ ID NO:1; (b) a peptide having the same amino acid sequence as shown in SEQ ID NO:1 except that one or several amino acids are deleted, substituted and/or added, the peptide having nasal mucosal permeability; (c) a peptide having an amino acid sequence represented by the reverse sequence of (a) or (b), the peptide having nasal mucosal permeability, with the proviso that a C-terminal amidated peptide is excluded. A hydrophilic bioactive substance having a low transmucosal absorption capability which has conventionally been able to be administered by only injection can be nasally administered. Such a pharmaceutical composition is useful for improvement of the pain and the inconvenience of patients caused by administration by injection.
A method for nasal administration of a drug comprising administering to the nasal mucosa of a patient in need thereof an effective amount of the pharmaceutical composition comprising a mixture of a peptide hormone or cytokine and any one of (a) to (c) below, with the proviso that a C-terminal amidated peptide is excluded:
Dependencies are inferred from the claim text.