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US 8,895,320 B2Granted
Filtration device for assays
AssigneeSilicon BioDevices, Inc.
InventorOctavian Florescu
Life of this patent
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Abstract
A device and method for filtering blood is disclosed herein. The device can filter blood and attach analytes within the blood to magnetic particles. The analytes can then be strongly bound to an analyzing device by a magnetic force. The analytes can then be counted by the analyzing device and the result can be displayed.
Claims14
A device for analyzing a biological fluid sample comprising:
- a filter configured to filter the biological fluid sample resulting in a filtrate comprising a target analyte;
- an exposed surface having a sensor area, wherein the sensor area comprises a sensor coated with a chemical specific for the target analyte;
- a vertical sedimentation capillary disposed above the sensor area having an outlet in proximity to the sensor area;
- a dried reagent at the top of the sedimentation capillary, wherein the reagent comprises magnetic particles functionalized to react with the target analyte;
- a delivery capillary having an inlet in proximity to the filter and an outlet fluidically connected to the sedimentation capillary, wherein the delivery capillary is configured to deliver the filtrate to the sensor area before the filtrate flows up the sedimentation capillary to the dried reagent;
- and
- wherein the magnetic particles can sediment through the sedimentation capillary to the exposed surface upon contact with the filtrate, and
- wherein the sensor is configured to detect magnetic particles that specifically bind to the sensor area.
5 more elements
A method for analyzing a biological fluid sample comprising:
- providing a device for analyzing the biological fluid sample having:
- an exposed surface having a sensor area, wherein the sensor area comprises a sensor coated with a chemical specific for a target analyte;
- a vertical sedimentation capillary disposed above the sensor area having an outlet in proximity to the sensor area;
- a dried reagent at the top of the sedimentation capillary comprising magnetic particles functionalized to react with the target analyte;
- and
- a delivery capillary having an inlet in proximity to a filter and an outlet that is fluidically connected to the sedimentation capillary;
- delivering the biological fluid sample onto the filter resulting in a filtrate comprising the target analyte;
- transferring the filtrate from the filter to the delivery capillary;
- transferring the filtrate through the delivery capillary to the exposed surface before the filtrate flows upward in the sedimentation capillary to the top of the sedimentation capillary, wherein the magnetic particles can sediment through the sedimentation capillary to the exposed surface;
- detecting, by the sensor, magnetic particles that specifically bind to the surface.
7 more elements
Dependencies are inferred from the claim text.