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US 8,895,301 B2Granted
Exogenous Pax6 nucleic acid expression in primate neural stem cells maintains proliferation without differentiation
AssigneeWisconsin Alumni Research Foundation
InventorsSu-Chun Zhang, Xiaoqing Zhang
Life of this patent
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Abstract
A transcription factor both necessary and sufficient for human neuroectoderm specification, Pax6, as well as applications thereof, is disclosed.
Claims11
An isolated primate primitive neural stem cell (primate pNSC) that overexpresses an exogenous Pax6 nucleic acid sequence, wherein said Pax6 expression is sufficient to maintain proliferating Pax6+/Sox1 primate pNSCs in vitro without differentiation.
Dependencies are inferred from the claim text.