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US 8,895,284 B2Granted
Class II human histone deacetylases, and uses related thereto
AssigneePresident and Fellows of Harvard College
InventorsChristina M. Grozinger, Christian A. Hassig, Stuart L. Schreiber
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Abstract
The invention provides histone deacetylase class II nucleic acids and polypeptides, methods and reagents for their use, and related compounds including small molecule libraries containing class II histone deacetylase inhibitors.
Claims23
A polypeptide comprising an amino acid sequence identical to SEQ ID NO:
- 4 fused to a heterologous polypeptide and/or fused to an epitope tag.
A polypeptide comprising an amino acid sequence identical to SEQ ID NO:
- 4 fused to a biotin moiety.
A polypeptide consisting of an amino acid sequence identical to SEQ ID NO:
- 9 fused to glutathione-S-transferase.
Dependencies are inferred from the claim text.